Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Overexpression of microRNA-200b-3p promoted lung adenocarcinoma cell proliferation and metastasis. 31795847

2020

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Mouse cell-derived xenograft and patient-derived xenograft model were also performed to evaluate the effects of miR-200b on tumor growth and metastasis in vivo. 31130475

2019

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE We aimed to evaluate the differential expression of miR-23b and miR-190 which are involved in tumor dormancy, miR-21 involved in metastasis and miR-200b and miR-200c involved in epithelial-mesenchymal transition (EMT) and metastasis, in the plasma of patients with early and metastatic breast cancer (MBC). 30847025

2019

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE We compared the miRNA expression profile of hematopoietic progenitors derived from pluripotent stem cells to those derived from bone marrow and found that numerous miRNAs are too highly expressed in hematopoietic progenitors derived from pluripotent stem cells, and that most of these are inhibitors of epithelial-mesenchymal transition or metastasis (including miR-200b, miR-200c, miR-205, miR-148a, and miR-424). 29047185

2018

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE HMGB3 promotes the proliferation and metastasis of glioblastoma and is negatively regulated by miR-200b-3p and miR-200c-3p. 30232806

2018

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Mechanistically, we show that miR-200b, a master regulator of EMT, directly targets and inhibits the expression of Kindlin-2, leading to the subsequent inhibition of EMT and metastasis. 29743493

2018

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in a murine claudin-low mammary tumor cell line. 29702103

2018

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE MiR-200b, miR-200c, and miR-141 have been confirmed to be related to tumor metastasis. miR-141 levels in serum from experimental group was higher significant compared to control group (p = 0.024). miR-200b levels in serum from experimental group was significantly increased compared to control group (p = 0.031). 28617555

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Importantly, overexpression of nontargetable PRDX2 eliminated the suppressive effects of miR-200b-3p on proliferation, invasion, EMT, chemotherapeutic resistance and metastasis of CRC cells. 29258530

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE The results also showed that miR-200b suppressed FUT4 expression and inhibited tumor growth and metastasis in MCF-7 and MDA-MB-231 breast cancer cells, as well as in the xenografted tumor tissues and metastatic lung tissues. miR-200b decreased the α1,3-fucosylation and LeY biosynthesis on epidermal growth factor receptor (EGFR), as well as inactivation of EGFR and downstream phosphoinositide-3 kinase/Akt signaling pathway. 28692034

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Overall, our study demonstrated how lncRNA XIST regulates CRC progression and metastasis by competing for miR-200b-3p to modulate the expression of ZEB1. lncRNA XIST may be used as a biomarker to predict prognosis in CRC patients. 28837144

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE MiR-200b expression was mainly associated with distant metastasis, whereas miR-155 correlated with local recurrence. 28347920

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Overexpression of miR-200b-3p and miR-429-5p significantly inhibited the proliferation, migration, and invasion of TNBC cells; suppressed the expression of markers for proliferation and metastasis in TNBC cells. 29156719

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Mechanistic investigations revealed that ARHGAP18 levels were controlled by miR-200b, the enforced expression of which was sufficient to activate RhoA, enhanced formation of focal adhesions and actin stress fibers, and reduced migration and metastasis. 28619708

2017

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE The present study aimed to determine whether miR‑200b was able to regulate the EMT of cervical cancer, in order to control metastasis. 26935796

2016

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1. 27044840

2016

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE The progression of DNA repair and cell proliferation in stage 1 bladder cancer ultimately results not only in the derepression of miR-200a and miR-200b but also in the regulation of the TNF pathway to metastasis-related genes or proteins, cell proliferation, and DNA repair in stage 4 bladder cancer. 27034531

2016

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE The results of the present study suggested that miR‑200b suppressed the migratory potential of cervical carcinoma cells and therefore their ability to metastasize by inhibiting the epithelial-mesenchymal transition, which may be utilized for the treatment of cervical cancer. 26935156

2016

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2. 26648487

2016

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE This study aimed to investigate the effect of miR-200b on ERM expression in a breast cancer cell line and its influence on invasion and metastasis ability in vitro. 27276064

2016

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Consistently, transfection with miR-200b, -192 or -215 mimic prevented the ability of Gα12QL to increase tumor cell migration/invasion. 25065598

2015

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE In conclusion, our findings identified the miR-200b/200c/429 subfamily as metastasis suppressor microRNAs in human HCC and highlighted the functional discrepancy among miR-200 family members. 25909223

2015

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE In the 173 gastric cancer samples, the low miR-200b expression group demonstrated a significantly poorer prognosis compared with the high miR-200b expression group and was associated with peritoneal metastasis. 25411357

2015

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE In the first phase, we selected candidate miRNAs associated with metastasis by analyzing the expression of 4 miR-200 family members (miR-200b, -200c, -141, and -429) in serum samples from 12 patients with stage I and IV CRC. 23982750

2014

Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE In contrast, forced expression of PKCα impairs the inhibitory effect of miR-200b on cell migration and tumor metastasis. 24925028

2014