Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE To explore the expression and predictive value of mir-489 and mir-21 in melanoma metastasis. 31624741

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Over expressed MiR-21 in prostate cancer is associated with metastasis and drug resistance to chemotherapy with Docetaxel. 29447469

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE In this review, I plan to place a special emphasis on HA/CD44-induced signaling pathways and the presence of several novel miRNAs (e.g., miR-10b/miR-302/miR-21) and lncRNAs (e.g., UCA1) together with their target functions (e.g., tumor cell migration, invasion, and chemoresistance) during cancer development and progression. 31293964

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Mir-371, mir-150, mir-21 and mir-7d were found to be potential prognostic markers, while mir-134, mir-146a, mir-338 and mir-371 were associated with metastases. 30579238

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Mechanistically, miR-21-5p and miR-155-5p were transferred to colorectal cancer cells by MDE and bound to the BRG1 coding sequence, downregulating expression of BRG1, which has been identified as a key factor promoting the colorectal cancer metastasis, yet is downregulated in metastatic colorectal cancer cells. 30401711

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Cell migration and invasion experiments were performed to evaluate the effects of miR‑21 and MKK3 on the cell metastasis of melanoma. 31257538

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Moreover, the expression levels of miR-182, miR-183, miR-141, and miR-21 were demonstrated to be associated with a gradual increase in fold change expression with depth of tumor invasion (all P < .05), lymph node invasion (all P < .001), and maximal increase with distant metastasis (all P < .001). 31764853

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Novel breast cancer screening: combined expression of miR-21 and MMP-1 in urinary exosomes detects 95% of breast cancer without metastasis. 31537868

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE We aimed to evaluate the differential expression of miR-23b and miR-190 which are involved in tumor dormancy, miR-21 involved in metastasis and miR-200b and miR-200c involved in epithelial-mesenchymal transition (EMT) and metastasis, in the plasma of patients with early and metastatic breast cancer (MBC). 30847025

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Previous reports showed an over-expression of miRNA-21 (miR-21) in various cancer cells, and its up-regulation is closely related to cancer initiation, proliferation and metastasis. 31284665

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE MicroRNA‑21 (miR‑21) has been revealed to play a crucial role in regulating the biological behavior, including proliferation, migration, invasion and metastasis in certain cancers. 30569149

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Transwell and wound healing assay were used to analyze breast cancer metastasis in response to miR-21 inhibitor. 31351450

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE High expression of miR-21 and low expression of miR-145 are closely related to the development and progression of CRC, especially with the grade of differentiation, invasion, metastasis and clinical stage. 29552756

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE The combined expression of miR-21-3p/miR-183-5p showed the best power to predict metastasis (AUC=0.804, <i>P</i>=4.67·10<sup>-18</sup>), and was found associated <i>in vitro</i> with pro-metastatic features, such as neuroendocrine-mesenchymal transition phenotype, and increased cell migration rate. 31410193

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE Ornithine aminotransferase promoted the proliferation and metastasis of non-small cell lung cancer via upregulation of miR-21. 30549035

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis. 31037150

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. 31384542

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE In addition, the expression levels between miR-155 and miR-21 and the relationship between the recurrence rate and metastasis of NSCLC were analyzed. 31289551

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE In conclusion, skeletal muscle mass may be a prognostic and predictive biomarker for distant metastasis in CRC patients and quantification of serum miR-21 expression could help clinicians make decisions regarding nutrition intervention strategies in CRC patients. 29484416

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein. 30140627

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE With the tumor, node, and metastasis stage developed (Stage I vs. III and IV, P < 0.05), the serum miR-21 expression level increased, but there was no statistical difference between Stage I patients and hepatolithiasis patients or healthy control (P > 0.05 for both). 29516989

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Meanwhile, mouse model of tumor peritoneal dissemination model was performed to investigate the role of exosomal miR-21-5p in peritoneal metastasis in vivo. 30154401

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE In the TCGA dataset, combined biomarkers associated with metastasis and overall survival (miR-21+142-5p+194: <i>P</i> < 0.0001; OR, 0.37; 95% CI, 0.58-0.23).<b>Conclusions:</b> The interconnected discovery-validation approach identified a three-miRNA signature as a potential predictor of disease outcome in RCC patients.<b>Impact:</b> With 10% survival at 5 years, metastatic disease presents poor prognosis for RCC patients. 29440068

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE The carcinogenic advantage generated by miR-21 in NSCLC resides in the target genes involved in multiple pathways such as cell growth and proliferation, angiogenesis, invasion and metastasis, but also chemo- and radioresistance. 30030592

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker BEFREE Here, we further observed the effect of ASOs against miR-21 on the growth and metastasis of CRC in vivo using a xenograft model of human CRC. 30317164

2018