Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Downregulation of Notch1 inhibits the invasion and metastasis of human gastric cancer cells SGC7901 and MKN74 in vitro through PTEN activation and dephosphorylation of Akt and FAK. 28627671

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The protein tyrosine phosphatase PRL-3 plays an important role in cancer cell migration, invasion and metastasis. 28980126

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE MiR-26a performs converse roles in proliferation and metastasis of different gastric cancer cells via regulating of PTEN expression. 28242043

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE MicroRNA-130b promotes proliferation and EMT-induced metastasis via PTEN/p-AKT/HIF-1α signaling. 26861561

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Finally, we identified that BMI-1 expression activating PI3K/AKT singing pathway by negative regulating PTEN was the main mechanism of promoting invasion and metastasis ability of pancreatic CSCs. 26840020

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) insufficiency is commonly found in breast cancer patients with metastasis. 27466505

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway. 26452025

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer. 28874658

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE MiR‑214 promotes osteosarcoma tumor growth and metastasis by decreasing the expression of PTEN. 26252022

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE EGFR4 and NMDAR2 mutations, MITF and MET amplifications and PTEN loss can be considered as metastasis drivers. 26970965

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. 25909289

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Our study demonstrated that, across diverse cancers, anomalies in specific tumor suppressor genes (PTEN, CDKN2A, APC, and/or TP53) were independently associated with a worse outcome, as reflected by time to metastases/recurrence, best PFS on treatment, and/or overall survival. 25928476

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN. 26299428

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models. 25515201

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE The absence of PTEN leads to caveolin-1 (CAV1)-dependent β-catenin transcriptional modulation in vitro, cooperates with NRAS(Q61K) to initiate melanomagenesis in vivo and induces efficient metastasis formation associated with E-cadherin internalization. 26307673

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Reduced PTEN level was correlated with the metastasis potential. 25909167

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Bioinformatics analysis combined with tumor metastasis PCR array showed that matrix metalloproteinase 2 (MMP2) and PTEN could be important target genes of miR-29b. 26063204

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Targets of miR-21 (TIMP3, PDCD4, PTEN, TPM1 and RECK) are also primarily involved in BC promotion and progression, especially invasion, angiogenesis and metastasis. miR-21 expression levels could perhaps be used in conjunction with the standard diagnostic parameters as an indicator of BC presence, and to indicate a phenotype likely to show early invasion/metastasis detection and poor prognosis. 26891730

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Reconstitution of PTEN rescues all phenotypes generated by EBV-miR-BART1, highlighting the role of PTEN in EBV-miR-BART-driven metastasis in NPC. 26135619

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Silencing PTEN formed high-grade carcinoma with wide spread tumor explants including metastasis into the ovary. 25971410

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Whether the loss of expression of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is associated with lymphatic-related metastasis needs elucidation. 25963289

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE In the present study we demonstrated that miR-221 promoted EHCC invasion and metastasis through targeting PTEN and formed a positive feedback loop with β-catenin/c-Jun signaling pathway. 26501139

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE PTEN loss in metastases appears to be associated with response to bevacizumab-based therapy. 24980447

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma. 24722280

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN. 25347742

2015