Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Knockdown of S100A4 blocks growth and metastasis of anaplastic thyroid cancer cells in vitro and in vivo. 27802204

2017

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The S100 calcium-binding protein A4 (S100A4) induces epithelial mesenchymal transition, migration, invasion, angiogenesis and metastasis. 28423501

2017

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE However, exact mechanisms how S100A4 stimulates metastasis in melanoma are still unknown. 26928771

2017

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE We found that abrogation of stromal BMPR2 expression via FSP1 driven Cre resulted in increased tumor metastasis. 25205038

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 and its role in metastasis – simulations of knockout and amplification of epithelial growth factor receptor and matrix metalloproteinases. 26057862

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 and its role in metastasis – computational integration of data on biological networks. 26118552

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2. 26487698

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4, also known as fibroblast-specific protein 1 or metastasin 1, is not only highly expressed in growth-stimulated cultured cells and metastatic tumor cells, but also in the periodontal ligament. 26499072

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4. 26741489

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 can be regarded as a negative prognostic biomarker or a metastasis-risk factor of human c-SCCs. 25171474

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. 24469032

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Expression of S100A4 protein in OS may be related to the prediction of metastasis potency, response to chemotherapy and poor prognosis for osteosarcoma patients, suggesting that S100A4 may serve as a prognostic marker for the optimization of clinical treatments. 24706307

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Previous studies have shown that elevated expression of S100A4 is associated with progression and metastasis of colorectal cancer (CRC). 24936148

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Increased expression levels of S100A4 associated with hypoxia-induced invasion and metastasis in esophageal squamous cell cancer. 25217321

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Thus, depending on the cell context, the metastasis-promoting effects of S100A4 may not be positively correlated with anticancer drug resistance in the clinic. 25310523

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4 mRNA expression was significantly correlated with tumor size, vascular invasion, node metastasis and tumor stage. 24706305

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis. 25311085

2015

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4, a small calcium-binding protein belonging to the S100 protein family, is commonly overexpressed in a variety of tumor types and is widely accepted to associate with metastasis by regulating the motility and invasiveness of cancer cells. 24732359

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Metastasin is a Ca(2+)-binding protein associated with tumor metastasis. 23483190

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE High expression of S100A4 and endoglin is associated with metastatic disease in head and neck squamous cell carcinoma. 24798676

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (NSCLC) tumors. 24215488

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is a known mediator of EMT, leading to metastasis and EMT has been proposed as a potential source of cancer-associated fibroblastic cells in solid tumors. 24037664

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Furthermore, Knockdown of MMP-9 by MMP-9 siRNA inhibited cell invasion and metastasis in the BCPAP/S100A4 cDNA, ML-1/S100A4 cDNA cells. 23771538

2013

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is a well established marker and mediator of metastatic disease, but the exact mechanisms responsible for the metastasis promoting effects are less well defined. 23832737

2013

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Regardless of histology, PTEN loss and diffuse S100A4 expression were associated with LN metastasis (P = 0.007, P = 0.013). 23580256

2013