Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE For example, AF1q has been shown to interact with T-cell Factor 7 (TCF7; also known as TCF1) from the Wnt/β-catenin pathway resulting in the transcriptional activation of the CD44 and the enhancement of breast cancer metastasis. 31541685

2020

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The serum CD44 level is closely related to disease progression and metastasis of malignancies. 31781712

2020

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The final nanoparticles (PCN-ACF-CpG@HA) can specifically target cancer cells overexpressing CD44 receptor though HA; the aggravated hypoxic survival signaling after PDT can be blocked by ACF to inhibit the HIF-1α induced survival and metastasis. 31746153

2020

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. 30860027

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The results revealed that the expression of NY-ESO-1/CD44/CD24 was associated with breast cancer metastasis. 31579408

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE CD44 expression was inversely associated with pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) and lymphatic invasion (p = 0.05). 30942083

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE To test whether endothelial cells (ECs) associated with lung metastases express a distinct gene expression program that promotes metastatic growth, we isolated CD31<sup>+</sup>/CD45<sup>-</sup> cells from lung mammary cancer metastases for RNA sequencing and found CD44 upregulation. 31722193

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE CD44+/CD24‑/low is currently the most commonly used marker for breast cancer stem cells (CSCs), which are considered the main cause of drug resistance, relapse and metastasis. 31545416

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE These results indicated that CC-CAFs-derived HGF induced up-regulation of CD44 which mediated adhesion of CRC cells to endothelial cells, and subsequently resulted in enhancement of metastasis of CRC cells, it could provide a novel therapeutic or preventive target. 31367190

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE In addition, functional assays showed that NNMT promoted HCC cell invasion and metastasis by altering the histone H3 methylation on 27 methylation pattern and transcriptionally activating cluster of differentiation 44 (CD44). 31294922

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Surprisingly, EPR and Dox combination significantly down-regulated the CD44 receptor expression which is the main contributing factor of tumor metastasis. 31086900

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE IMPLICATIONS: Expression of CD44 promotes spheroid formation, mesothelial adhesion, and formation of mesenteric metastasis, but it suppresses development of metastasis to several peritoneal sites, including liver, and the thoracic cavity. 31147393

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE Recently, cluster of differentiation 44 (CD44) has been shown to be associated with tumor initiation, metastasis and prognosis. 30348713

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE A correlation with EMT was supported by an increase in CD44 in vertebral metastases and parenchymal metastases. 31064271

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Aggregated tumor cells exhibited enriched expression of the breast cancer stem cell marker CD44 and promoted tumorigenesis and polyclonal metastasis. 30361447

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Additionally, CD44 was shown to be associated with some clinicopathological features, such as lymph node metastasis (OR<sub>CD44</sub> = 1.56, 95% CI = 1.01-2.41, <i>P</i> = 0.044; OR<sub>CD44v6</sub> = 1.97, 95% CI = 1.19-3.26, <i>P</i> = 0.008; OR<sub>Total CD44 isoforms</sub> = 1.57, 95% CI = 1.15-2.14, <i>P</i> = 0.004), distant metastasis (OR<sub>CD44</sub> = 2.90, 95% CI = 1.08-7.83, <i>P</i> = 0.035; OR<sub>Total CD44 isoforms</sub> = 1.89, 95% CI = 1.02-3.53, <i>P</i> = 0.044). 31114754

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Triple negative breast cancers (TNBC) are aggressive, difficult to treat, and contribute to high incidences of metastasis by possessing characteristics such as increased tumor cell migration and a large presence of the transmembrane protein, cluster of differentiation 44 (CD44) on the cell membrane. 31496817

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The expression of CD44 and CD90 in gastric cancer tissues was associated with distant metastasis and the differentiation state of tumors. 31073886

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas. 31417182

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Taken together, the novel CD44 targeted TN-CCLP exhibited the potential for inhibiting tumor development and metastasis through improving inflammatory infiltration of tumor tissue. 30668131

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE In 4T1-luc metastatic breast cancer model in mice, Sap-EGFR/CD44-NGs exhibited significant inhibition of tumor metastasis to lung at a small dose of 3.33 nmol Sap equiv./kg. 30699364

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE While expression of CSC markers CD44, CD133 and aldehyde dehydrogenase 1 (ALDH1) in locoregional gastroesophageal cancer is known to be associated with poorer clinical outcomes, the significance of CSC marker expression in distal metastatic disease is unknown. 31230819

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Tumours with the infiltrating pattern were associated with high FIGO grade (P = 0.002), reduced ER and PR, and CD44 expression (P = 0.014, 0.026, and 0.030, respectively); those with a MELF pattern showed LN metastasis (P < 0.001), lymphovascular invasion (P = 0.011), and reduced ER, CD44, and CD133 expression (P = 0.036, 0.006, and 0.016, respectively). 28990139

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma. 30561155

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. 31175290

2019