Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE In this study, anaplastic lymphoma kinase (<i>ALK</i>) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT) protein expressionwere studied to investigate potential correlations between these molecular characteristics and clinical features or outcomes in neuroblastoma. 28546523

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE In this mini-review, we will discuss the research progress of TERT-mediated and ATRX-mediated telomere maintenance and NB, especially high-risk tumors. 28452859

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE In this study, TERT rearrangements were examined in NBLs along with their relationship to other aspects of telomere biology. 27793328

2016

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE A total of 378 breakpoints common to the primary tumor and cfDNA of any given patient were identified, 27 breakpoints were seen by tumor aCGH, and 54 breakpoints were seen in cfDNA only, including two cases with interstitial IGFR1 gains and two alterations targeting TERT CONCLUSIONS: These results demonstrate the feasibility of cfDNA copy number profiling in neuroblastoma patients, with a concordance of the overall genomic profile in aCGH and cfDNA dynamic cases of 97% and a sensitivity of 77%, respectively. 27440268

2016

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase reverse transcriptase gene (TERT). 26466568

2015

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors. 26523776

2015

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Recurrent pre-existing and acquired DNA copy number alterations, including focal TERT gains, in neuroblastoma central nervous system metastases. 24123354

2013

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE Thus, hTERT mRNA might be a potential marker for estimating the malignancy of pheochromocytomas and neuroblastomas. 15004408

2004

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Full-length telomerase reverse transcriptase messenger RNA is an independent prognostic factor in neuroblastoma. 12598334

2003

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE Regulation of telomerase activity by alternate splicing of human telomerase reverse transcriptase mRNA in a subset of neuroblastomas. 11696453

2001