Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 GeneticVariation BEFREE Deleterious mutations were identified in 10.7% of women, including 6.1% in BRCA1/2 (5.1% in non-Ashkenazi Jewish patients) and 4.6% in other breast/ovarian cancer predisposition genes including CHEK2 (n = 10), ATM (n = 4), BRIP1 (n = 4), and one each in PALB2, PTEN, NBN, RAD51C, RAD51D, MSH6, and PMS2. 26976419

2016

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 GeneticVariation BEFREE Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures. 24879340

2015

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 GeneticVariation BEFREE Our findings suggest that CHEK2 mutations may not contribute significantly to breast/ovarian cancer risk in Pakistani women. 23806170

2014

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 GeneticVariation BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112

2014

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 Biomarker BEFREE Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer. 24657486

2014

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 Biomarker BEFREE Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers. 17145815

2007

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 GeneticVariation BEFREE Positive associations were seen with the CHEK2 I157T missense variant and ovarian cystadenomas (OR = 1.7; P = 0.005), with borderline ovarian cancers (OR = 2.6; P = 0.002) and with low-grade invasive cancers (OR = 2.1; P = 0.04). 16828850

2006

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.380 GeneticVariation BEFREE Analysis of CHEK2 gene for ovarian cancer susceptibility. 15385111

2004