Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.050 AlteredExpression BEFREE PARP inhibitors (PARPis) have remarkable antitumor activity in BRCA mutant ovarian carcinoma. 30666631

2019
Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.050 Biomarker BEFREE Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma. 30266954

2018
Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.050 AlteredExpression BEFREE We showed that PARP1 is highly expressed in specimens of high grade serous ovarian carcinoma and its activity is required for unperturbed proliferation of ovarian cancer cells. 29684820

2018
Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.050 AlteredExpression BEFREE Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. 28882436

2017
Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.050 AlteredExpression BEFREE CDK12 is a recurrently mutated gene in serous ovarian carcinoma, whose downregulation is associated with impaired expression of DNA damage repair genes and subsequent hypersensitivity to DNA-damaging agents and PARP1/2 inhibitors. 26787835

2016