Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines. 26267321

2016

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE TRIM27 knockdown induced cell cycle arrest and apoptosis in ovarian cancer cells by upregulating the expression of p-P38 and downregulating the expression of p-AKT. 26568293

2016

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Pyruvic acid and NAD+/NADH levels also changed when miR-29b expression was suppressed; this effect could be blocked by specific AKT inhibitors, suggesting the miR-29b-AKT axis regulates the Warburg effect in ovarian cancer. 26512921

2016

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Furthermore, in a phase I clinical study, the catalytic Akt inhibitor AZD5363 induced partial responses in patients with breast and ovarian cancer with tumors containing AKT1(E17K) mutations. 26351323

2016

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Knockdown of CDK5 with siRNAs inhibits activation of AKT which significantly correlates with decreased cell growth and enhanced paclitaxel sensitivity in ovarian cancer cell lines. 26146988

2016

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The importance of the PI3K/AKT/MTOR pathway in the progression of ovarian cancer. 23591839

2015

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Furthermore, overexpression of miR‑338‑3p inhibited phosphorylation of PI3K and AKT, which contributed to suppression of ovarian cancer cell growth. 25776272

2015

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Crk-like adapter protein is required for TGF-β-induced AKT and ERK-signaling pathway in epithelial ovarian carcinomas. 25307974

2015

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE CXCR7 signaling induced epithelial-mesenchymal transition by AKT and ERK pathways in epithelial ovarian carcinomas. 25359618

2015

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. 25677064

2015

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas. 24036443

2014

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway. 23869765

2014

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Moreover, VEGF expression could reverse the effect of miR-718 on ovarian cancer by increasing the levels of phosphorylated AKT. 24815691

2014

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 PosttranslationalModification BEFREE AKT phosphorylation is associated with ARID1A/BAF250a deficient tumors, however in ovarian cancers the mechanism remains to be elucidated. 24559118

2014

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE We assess key issues in anti-angiogenic treatment including potential ways for addressing resistance; we review the current studies of PARP inhibitor treatment, which shows most promise in patients with germline BRCA mutations; we describe the potential for folate-receptor-directed therapy, given the high level of FR expression in ovarian cancer and we highlight the potential for molecular targeted therapy, focusing on specific subgroups of the disease with targets such as the PI3 K/AKT and RAS/RAF/MEK pathways and the ErbB family of oncogenes. 24265409

2014

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Immune escape of AKT overexpressing ovarian cancer cells. 23467686

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells. 23178716

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE In this study, we show that bortezomib induced apoptosis, which was demonstrated by the downregulation of antiapoptotic molecules (Bcl-2, Bcl-XL, p-Bad, and p-AKT) and the upregulation of proapoptotic proteins (p21, p27, and cleaved-Bid) in ovarian cancer cell lines. 23449448

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Reduction of SRPK1 expression using small interfering RNA (siRNA) encoding small hairpin RNA in ovarian cancer cells led to (i) reduced cell proliferation rate, slower cell cycle progression and compromised anchorage-independent growth and migration ability in vitro, (ii) decreased level of phosphorylation of multiple serine-arginine proteins, and P44/42MAPK and AKT proteins, and (iii) enhanced sensitivity to cisplatin. 23236423

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells. 23948303

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian carcinoma. 23408974

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE We also discovered that VP-128 induces autophagy in ovarian cancer cells because of the formation of acidic vesicular organelles (AVOs) and increase of Light Chain 3B-II protein responsible for the formation of autophagosomes; pathways related to autophagy (AKT and mammalian target of rapamycin) were also down-regulated, supporting this mechanism. 23677930

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Furthermore, our study also indicated that the PI3K/AKT and p38MAPK signaling pathways might contribute to WAVE1 promotion of ovarian cancer cell proliferation, migration, and invasion. 23680521

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Genomic complexity and AKT dependence in serous ovarian cancer. 22328975

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Nuclear localization depended on AKT, which was constitutively active in ovarian cancer cells. 22389439

2012