Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens. 28073843

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis. 28859612

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Accordingly, immunohistochemical analysis of ERα-negative tissue specimens from HGSOC patients showed a significantly greater TAM infiltration in premenopausal compared to postmenopausal women. 26797759

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. 26698676

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models. 26344002

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE These associations were stronger for serous ovarian cancer and for estrogen receptor-negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10(-5) and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10(-5), respectively). 26586665

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Estrogen receptor-mediated miR-486-5p regulation of OLFM4 expression in ovarian cancer. 26871282

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE BRCA mutations were detected in 26 of 92 patients (28%) with ovarian cancer, in 14 of 96 patients (15%) with breast cancer overall, and in 9 of 33 patients (27%) who had tumors that were negative for estrogen receptor, progesterone receptor, and human epithelial growth factor 2 (triple-negative breast cancer). 25236687

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice. 24410765

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Molecular analyses showed that leptin increased human telomerase reverse transcriptase (hTERT) mRNA expression and cell growth through estrogen receptor-α (ERα) activation in ovarian cancer cells, which was suppressed by 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3]. 25252917

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Recurrent estrogen receptor α (ERα)-positive breast and ovarian cancers are often therapy resistant. 25825714

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 PosttranslationalModification BEFREE Estrogen receptor promoter methylation predicts survival in low-grade ovarian carcinoma patients. 24908329

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE This growth promoting effect of OC cell growth was mediated by miR-26a inhibition of the posttranscription of ER-α. 24466274

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE There was significant enrichment of ESR1 binding present in multiple datasets near genomic regions associated with breast cancer (7.45-fold, p = 0.001), height (2.45-fold, p = 0.002), multiple sclerosis (5.97-fold, p < 0.0002) and prostate cancer (4.47-fold, p = 0.0008), and suggestive evidence of ESR1 enrichment for regions associated with coronary artery disease, ovarian cancer, Parkinson's disease, polycystic ovarian syndrome and testicular cancer. 24171864

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Resveratrol regulates the cell viability promoted by 17β-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor α and insulin growth factor-1 receptor in BG-1 ovarian cancer cells. 23810794

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Blocking cross-talk between ER and constitutively activated kinase pathways may improve anti-estrogen therapeutic efficacy in OVCA, as has been demonstrated in other cancers. 23402742

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE In this study, we investigated the effects of ERβ ectopic expression on 17β-estradiol (E2)-induced transactivation and cell proliferation in ERα-positive BG1 ovarian cancer cells. 23885094

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer. 24376209

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Saracatinib augments effects of fulvestrant by opposing estrogen-mediated Src activation and target gene expression, increasing cell-cycle arrest, and impairing survival, all of which would oppose antiestrogen resistance in these ER+ ovarian cancer models. 22896656

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The novel estrogen receptor GPER regulates the migration and invasion of ovarian cancer cells. 23580092

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Exploiting MEK inhibitor-mediated activation of ERα for therapeutic intervention in ER-positive ovarian carcinoma. 23390495

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE The majority of ovarian cancers over-express the estrogen receptor (ERα) and grow in response to estrogens. 22549810

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Meanwhile, the at-risk A allele was positively related with the occurrence of mucinous ovarian cancer (OR = 3.48; 95% CI:1.15-6.83; P = 0.001), low degree of differentiation (OR = 1.87; 95% CI:1.03-3.47; P = 0.003), lymph node metastasis (OR = 1.69; 95% CI: 1.14-2.75; P = 0.010) and estrogen receptor positive (OR = 2.72; 95% CI: 1.38-4.81; P = 0.002). 23095717

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Expression of PR and ESR1 defines a subgroup of ovarian carcinomas with a favourable prognosis. 22092403

2012

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. 22351618

2012