Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE The incidence of germline MMR gene mutations in ovarian cancer is only 2% but other mechanisms of gene inactivation mean that loss of expression of one of the seven main genes (MSH2, MSH3, MSH6, MLH1, MLH3, PMS1 and PMS2) occurs in up to 29% of cases. 24333356

2014

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Our findings suggest that fewer than 1% of women with ovarian cancer harbour a germline mutation in the HNPCC genes, with overrepresentation of MSH6 mutations. 23047549

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE One patient (44 y, with MSH2 mutation) was found to have a mixed endometrioid/clear cell OC and simple EH without atypia. 23426126

2013

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE On contrast to endometrial and ovarian cancer, which occurred significantly more often and at younger age in MLH1/MSH2 mutation carriers (median 50.5 and 49.0 years; P < 0.00001), overall cumulative breast cancer incidence closely mirrored the one in the Swiss population (56.5 years). 22034109

2012

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE We report on an ovarian cancer patient who carries a germline MSH2 c.1A>C variant which alters the translation initiation codon. 21837758

2012

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE MMR-deficient ovarian cancer is frequently associated with loss of expression of MSH2 and MSH6 proteins and clear cell histology. 18469706

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Ovarian cancer (N = 72) had an lifetime risk of 6.7% (95% CI: 5.3-9.1); risks were higher in women born after the median year of birth (p < 0.008) and in members of MSH2 families (p < 0.006). 18398828

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma. 16941012

2007

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Limiting genetic evaluation to women with synchronous endometrial and ovarian cancer who have a family history suggestive of HNPCC may appropriately identify women with Lynch syndrome. 16361634

2006

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE This review examines a number of proto-oncogenes and tumor suppressor genes that are associated with ovarian carcinomas, including p53, BRCA1, and BRCA2; mismatch repair genes such as hMSH2 and hMLH1; and PTEN, HER-2/neu, K-ras, fms, and AKT2. 11123866

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after 5 or 6 courses of CDDP-based chemotherapy in the 24 cases of ovarian cancer. 11592780

2001

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 PosttranslationalModification BEFREE Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells. 11350971

2001

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE We calculated age related risks of all, colorectal, endometrial, and ovarian cancers in nt943+3 A-->T MSH2 mutation carriers (n=76) for all patients and for men and women separately. 10051005

1999

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE hMLH1 and hMSH2 expression and BAX frameshift mutations in ovarian cancer cell lines and tumors. 9600357

1998

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE The fact that we found no germline pathologic mutations in hMSH2 and hMLH1 (predominant sites of mutation in HNPCC) in MIN+ OC cases, suggests that the genetic basis of MIN in OC can be different from that in HNPCC; our finding that distinct microsatellite banding patterns largely distinguish sporadic from familial OC, may reflect the involvement of different DNA repair genes in MIN in individual OC cases. 8824498

1996

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Microsatellite instability and alterations in the hMSH2 gene in human ovarian cancer. 8550235

1996

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE This review discusses recent insights into the roles of the p53 tumor-suppressor gene and growth factors in the development of ovarian cancer and describes the genes implicated in familial ovarian cancer syndromes related to the MSH2 (Lynch II) and BRCA1 (breast and ovarian cancer) genes. 7827156

1995

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Amongst the important known susceptibility genes are those dominant genes conferring a high risk of breast and ovarian cancer (BRCA1), colon cancer (hMSH2 and hMLH1), and melanoma (MLM). 7987639

1995

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE The genetic instability observed in the tumor and cell line DNA, together with the germ-line mutation in a mismatch-repair gene, suggest that the MSH2 gene is involved in the onset and/or progression in a subset of ovarian cancer. 7937795

1994