Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Evaluation of copy number variation (CNV) in BRCA1/2 genes, due to large genomic rearrangements (LGRs), is a mandatory analysis in hereditary breast and ovarian cancers families, if no pathogenic variants are found by sequencing. 28465148

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE We report a novel BRCA1 LGR, involving the complete duplication of exon 3, in an Italian patient with a strong family history of breast and ovarian cancer. 28488140

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting. 28525389

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 AlteredExpression BEFREE Poly (ADP-ribose) polymerase 1 (PARP1) is overexpressed in a variety of cancers, especially in breast and ovarian cancers; tumor cells that are deficient in breast cancer gene 1/2 (BRCA1/2) are highly sensitive to PARP1 inhibition. 28770827

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Diagnostic markers for the detection of ovarian cancer in BRCA1 mutation carriers. 29244844

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Combined annotation-dependent depletion score for BRCA1/2 variants in patients with breast and/or ovarian cancer. 29215753

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Germline mutations in BRCA1/BRCA2 significantly increase the risk of breast and ovarian cancer in women. 28780755

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Baseline clinical predictors of antitumor response to the PARP inhibitor olaparib in germline BRCA1/2 mutated patients with advanced ovarian cancer. 28454085

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. 28090007

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE BRCA1 germline mutation confers hereditary predisposition for breast and ovarian cancer. 29034880

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE High-grade epithelial ovarian carcinomas containing mutated <i>BRCA1</i> or <i>BRCA2</i> (<i>BRCA1/2</i>) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and PARP inhibitors (PARPi), while restoration of HR function due to secondary mutations in <i>BRCA1/2</i> has been recognized as an important resistance mechanism. 28588062

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Clinical characteristics and outcomes of patients with BRCA1 or RAD51C methylated versus mutated ovarian carcinoma. 29233532

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Predictability of BRCA1/2 mutation status in patients with ovarian cancer: How to select women for genetic testing in middle-income countries. 28619461

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Association of BRCA1/2 mutations with ovarian cancer prognosis: An updated meta-analysis. 29480828

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Chemosensitivity of BRCA1-Mutated Ovarian Cancer Cells and Established Cytotoxic Agents. 28604461

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Approximately 20% of high-grade serous ovarian cancers are homologous-recombination (HR)-deficient due to genetic and epigenetic mutations of HR pathway genes including the tumor suppressor genes BRCA1 and 2. 28866885

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Genetic Versus Epigenetic BRCA1 Silencing Pathways: Clinical Effects in Primary Ovarian Cancer Patients: A Study of the Tumor Bank Ovarian Cancer Consortium. 28691938

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells. 28432813

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 Biomarker BEFREE Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention. 28264838

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Germline mutations in established moderately or highly penetrant risk genes for breast cancer (BC) and/or ovarian cancer (OC), including BRCA1 and BRCA2, explain fewer than half of all familial BC and/or OC cases. 28033443

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers. 28377179

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE We analyzed histone deacetylase 10 (HDAC10) for function in the context of the DNA damage response in BRCA1-null ovarian cancer cells as well as evaluated the potential of general HDAC inhibitors in primary ovarian carcinoma cells. 28073598

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE BRCA1 and BRCA2 mutations in ovarian cancer patients from China: ethnic-related mutations in BRCA1 associated with an increased risk of ovarian cancer. 28176296

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers. 28376175

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.400 GeneticVariation BEFREE Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. 28882436

2017