Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 Biomarker BEFREE We found an increased frequency of deleterious mutations in BRIP1 in case patients (0.9%) and in the UKFOCSS participants (0.6%) compared with control patients (0.09%) (P = 1 x 10(-4) and 8 x 10(-4), respectively), but no differences for BARD1 (P = .39), NBN1 ( P = .61), or PALB2 (P = .08). 26315354

2015

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 GeneticVariation BEFREE We analyzed the prevalence and spectrum of germline mutations in PALB2 to estimate their contribution to hereditary breast and/or ovarian cancer in the Czech Republic. 24136930

2014

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 GeneticVariation BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112

2014

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 Biomarker BEFREE PALB2 heterozygotes were 4-fold more likely to have a male relative with breast cancer (P = 0.0003), 6-fold more likely to have a relative with pancreatic cancer (P = 0.002), and 1.3-fold more likely to have a relative with ovarian cancer (P = 0.18). 21285249

2011

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 GeneticVariation BEFREE We conclude that germline mutations of PALB2 do not significantly contribute to cancer risk in non-BRCA1/2 cancer families with at least one patient with ovarian cancer, male breast cancer, and/or pancreatic cancer. 20582465

2011

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 GeneticVariation BEFREE Two truncating mutations in PALB2 (Q66X and W1038X), one of which is has not been reported before, were detected in an independent Australian cohort of 70 individuals with breast or ovarian cancer, and have strong family histories of breast or breast/ovarian cancer. 21409391

2011

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 Biomarker BEFREE PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. 20332121

2010

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 GeneticVariation BEFREE Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families. 18501021

2009

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.390 GeneticVariation BEFREE Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer. 18281473

2008