Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Importantly, expression of FGF5 and phospho-HER2 correlated with a reduced pathologic complete response rate in patients with HER2 positive breast cancer treated with neoadjuvant trastuzumab which highlights the significant role of TAFs/FGF5 in HER2 breast cancer progression and resistance. 31699826

2020

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The human epidermal growth factor receptor 2 (HER2) plays an essential role in the tumorigenesis and tumor progression in cancer. 31829777

2020

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The expression of MTDH in tumor tissues of patients with HER2-positive locally advanced breast cancer was significantly elevated, which was related to the poor pathological features.High MTDH expression was closely correlated with poor prognosis of patients and was an important factor affecting tumor progression. 31490377

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE GPAA1 facilitates the expression of cancer-related GPI-anchored proteins and supplies a more robust platform-the lipid raft-to promote EGFR-ERBB2 dimerization, which further contributes to tumour growth and metastasis and to cancer progression. 31118109

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Improving the outcome of patients with HER2-negative metastatic breast cancer experiencing tumour progression following first-line chemotherapy remains an urgent medical need. 31115844

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE ERBB2 Regulates MED24 during Cancer Progression in Mice with <i>Pten</i> and <i>Smad4</i> Deletion in the Pulmonary Epithelium. 31248101

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE HER2dMAb delayed tumor progression for HER2-expressing ovarian and breast cancer models. 30996140

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. 31493743

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE HUNK is a protein kinase that is implicated in HER2-positive (HER2+) breast cancer progression and resistance to HER2 inhibitors. 30542510

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Several investigations reported that HER-2 (ErbB-2 receptor) and Epstein-Barr virus (EBV) are important etiological factors in human gastric cancer, where either oncogene/oncovirus alone can derive a major event of cancer progression and metastasis via epithelial-mesenchymal transition (EMT). 28562165

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Although this serum biomarker will not replace the direct measurement of tumor HER2 status for diagnosis of early-stage tumors; it might be especially useful in metastatic disease for prognosis, as an indicator of cancer progression and of therapy response, particularly to anti-HER2 therapies. 29491426

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE A Prediction Model of Tumor Progression and Survival in HER2-Positive Metastatic Gastric Cancer Patients Treated with Trastuzumab and Chemotherapy. 29845329

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The aim of this study was to evaluate the efficacy of adenovirus mediated HER2-siRNA in combination with cisplatin (Ad-HER2-siRNA+DDP) on treating HER2-positive ovarian cancer xenografts and explore the effectiveness of <sup>131</sup>I-Herceptin immunoSPECT imaging for monitoring the tumor's progression. 30052070

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 20% to 30% of breast cancers and various other types of cancers, which plays a vital role in the cancer progression. 29455083

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Moreover, there is little information available on HER2 status role in tumor progression and metastasis in colorectal carcinoma (CRC) compared to other solid tumors. 29504811

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Thus, with previous experimental evidences, the present review discussed the role of FoxOs in association with metastasis related molecules including cannabinoid receptor 1 (CNR1), Cdc25A/Cdk2, Src, serum and glucocorticoid inducible kinases (SGKs), CXCR4, E-cadherin, annexin A8 (ANXA8), Zinc finger E-box-binding homeobox 2 (ZEB2), human epidermal growth factor receptor 2 (HER2) and mRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-622, subsequently analyzed the molecular mechanism of some natural compounds targeting FoxOs and finally suggested future research directions in cancer progression and metastasis. 28774834

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE In breast cancer, HER2 overexpression is a prognostic factor in advanced cases and is associated with tumor progression in ductal carcinoma in situ. 30120594

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Its contribution in dampening cancer progression is mainly attributed to the antibody-dependent cell-mediated cytotoxicity (ADCC) rather than HER2 blockade. 29700387

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Sequential blockade of HER2 followed by JAGGED1 or NOTCH could be more effective than simultaneous blockade to prevent drug resistance and tumor progression.<i></i>. 29895705

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE COX2 and HER2 are shown to be critical in the regulation of cancer progression. 29873317

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Recently, we have shown that MUC13, which is highly expressed in pancreatic tumors, promotes tumor progression via modulation of HER2 receptor tyrosine kinase activity. 29467405

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Overexpression of human epidermal growth factor receptor 2 (HER2) plays important roles in tumorigenesis and tumor progression in breast cancer. 28104744

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Overexpression of HER2, a receptor tyrosine kinase of the ERBB family, in breast cancer is related to increased cancer progression and aggressiveness. 28492659

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Resistance to human epidermal growth factor receptor-2 (HER2)-targeted therapies is common, and results in treatment failure and new tumor progression. 28859163

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE However, IFN-γ had no effect on tumor progression in the CT26/HER2 model, as determined by an IFN-γ knockout assay. 28460461

2017