Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Recent findings show that over-expression or mutation of Set2 enzymes promotes cancer progression, however, mechanisms of H3K36me are poorly understood. 31439846

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE More so, inhibiting HIF-1 activity restricted cancer progression. 31485300

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Advanced tumors typically have regions of chronic hypoxia, activating the transcription factor, HIF-1, which controls the expression of genes involved in cancer progression. 30669593

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Since hypoxia and Hypoxia Inducible Factor-1 (HIF-1) have been associated with treatment failure and tumor progression, we hypothesized that EGFR/mammalian Target Of Rapamycin (mTOR)/HIF-1 axis inhibition could radiosensitize HNSCC. 31640284

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Role of HIF-1 in Cancer Progression: Novel Insights. A Review. 30411685

2018

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Identifying the interplay between HIF-1 and components of the calcium signal will give new insights into mechanisms underlying cellular responses to physiological and pathophysiological cues, and may provide novel and more efficient therapeutic strategies for the control of cancer progression. 29407528

2018

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The unique ability of PIM inhibitors to concomitantly target HIF1 and selectively kill hypoxic tumor cells addresses two major components of tumor progression and therapeutic resistance.<i></i>. 29084916

2018

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) play important roles in cancer progression in various cancer cell lines. 29630948

2018

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Here, we report that p53 mutants influence the tumor microenvironment by cooperating with HIF-1 to promote cancer progression. 30381462

2018

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia-inducible factor 1 (HIF-1) is a major mediator of the hypoxic response involved in tumor progression. 28380438

2017

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes involved in tumor progression in various cancers. 28558056

2017

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor progression. 27742687

2017

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These studies have important implications on the role of SETD2 mutations in promoting genomic instability and tumor progression. 27528705

2016

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Using the cell-based reporter assay, we identified several oncogenic pathways modulated by sulforaphane in hypoxia by activating anticancer responses (p53, ARE, IRF-1, Pax-6 and XRE) and suppressing responses supporting tumor progression (AP-1 and HIF-1). 25955133

2015

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE As NSD1 and SETD2 are known tumor suppressors and loss of H4K20 trimethylation is an early event in cancer progression, which contributes to genomic instability, we propose DMAPT as a potent pharmacologic agent that can reverse NF-κB-dependent and -independent cancer-specific epigenetic abnormalities. 25611383

2015

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. 23435419

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway. 25451255

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Altogether, we have identified a previously unappreciated mechanism by which HIF-1 suppresses FAO to facilitate cancer progression. 25242319

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, which are involved in multiple aspects of tumorigenesis and cancer progression, including proliferation, metabolism, angiogenesis, invasion, metastasis and therapy resistance. 25101278

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis through various mechanisms, and HIF-1α polymorphisms are reportedly associated with many cancers; however, the associations of HIF-1α P582S and A588T polymorphisms with the risk of digestive system cancer remain inconclusive. 24293391

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE HIF-1 is also activated in cancer cells by tumor suppressor (e.g., VHL) loss of function and oncogene gain of function (leading to PI3K/AKT/mTOR activity) and mediates metabolic alterations that drive cancer progression and resistance to therapy. 23999440

2013

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE HIF-1 activates various genes in cancer progression and metastasis. 24260383

2013

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia-inducible factor-1 (HIF-1) and its most important subunit, HIF-1α, plays a central role in tumor progression by regulating genes involved in cancer cell survival, proliferation and metastasis. 22355351

2012

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia inducible factor-1 (HIF-1) is a bHLH-family transcription factor that controls genes involved in glycolysis, angiogenesis, migration, as well as invasion factors that are important for tumor progression and metastasis. 21814878

2012

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Breast cancers contain regions of intratumoral hypoxia in which reduced O(2) availability activates the hypoxia-inducible factors HIF-1 and HIF-2, which increase the transcription of genes encoding proteins that are required for many important steps in cancer progression. 22921864

2012