Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Given the inhibitory effect of salidroside on HIF-1α expression, our data suggested that: (1) LOXL2 was the mechanism, whereby salidroside and KC7F2 showed inhibitory effect on cancer progression of BxPC-3 cells; (2) salidroside exerted its anticancer effect, most likely, by a HIF-1α/LOXL2 pathway. 31162697

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE In conclusion, HDAC1 promotes glycolysis in GC and affects HIF-1α activity in tumor progression and metastasis. 30500418

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE A negative correlation was determined between miR-548c-3p and hypoxia-inducible factor (HIF) 1α or vascular endothelial growth factor (VEGF) levels, indicating that miR-548c-3p inhibited tumor progression by suppressing the HIF1α-mediated VEGF signaling pathway. 31378898

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE More so, inhibiting HIF-1 activity restricted cancer progression. 31485300

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Hypoxia is a major factor in tumor progression and resistance to therapies, which involves elevated levels of the transcription factor HIF-1a. 31848297

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Taken together, our results indicate that increased expression of MTFR2 is associated with tumour progression in breast cancer cells through switching glucose metabolism from OXPHS to glycolysis in a HIF1α- and HIF2α-dependent manner. 31740625

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Advanced tumors typically have regions of chronic hypoxia, activating the transcription factor, HIF-1, which controls the expression of genes involved in cancer progression. 30669593

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia Inducible Factor-1α (HIF-1α) is involved in cancer progression and is stabilized by the chaperone HSP90 (Heat Shock Protein 90), preventing degradation. 31486323

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE HIF-1α acts as an important transcriptional regulator directly or indirectly associated with genes involved in cell proliferation, angiogenesis, apoptosis and energy metabolism during tumor progression in hypoxic microenvironment. 30876462

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Since hypoxia and Hypoxia Inducible Factor-1 (HIF-1) have been associated with treatment failure and tumor progression, we hypothesized that EGFR/mammalian Target Of Rapamycin (mTOR)/HIF-1 axis inhibition could radiosensitize HNSCC. 31640284

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Importantly, HIF-1α regulates various steps of cancer progression such as cell survival, tumor cell invasion, and metastasis. 31521236

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Furthermore, we demonstrated that PTGIS is a HIF-1α targeted gene, a major regulator in hypoxic cancer progression by activating transcription of various oncogenes. 30315244

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Here, we report that p53 mutants influence the tumor microenvironment by cooperating with HIF-1 to promote cancer progression. 30381462

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE ALPPS induced: tumor progression on deportalized lobe and metastases; expression of hepatic vasculogenic factors (HIF1-α and VEGF); and a dramatic increase of Kupffer cells (KCs) and tumor-associated macrophages (TAMs). 29795479

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) play important roles in cancer progression in various cancer cell lines. 29630948

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation. 30254159

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Taken together, our data demonstrates that high levels of ∆Np73 stabilize HIF-1α protein, allowing for it to accumulate and further potentiating its transcriptional activity and supporting tumor progression. 29628507

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Of the diverse effects of HIF-1α on cancer progression, hypoxia-induced cell migration was investigated. 29760417

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Finally, inhibition of proline biosynthesis significantly enhanced cytotoxicity of sorafenib <i>in vitro</i> and <i>in vivo</i><b>Conclusions:</b> Our results demonstrate that hypoxic microenvironment activates proline metabolism, resulting in accumulation of hydroxyproline that promotes HCC tumor progression and sorafenib resistance through modulating HIF1α. 29084919

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Tumor oxygenation mediated by M-Abx specifically occurs within the H2O2-overexpressed tumor microenvironment, and significantly downregulates the content of tumor progression-related proteins, such as HIF-1α, P-gp, and VEGF. 30420976

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Role of HIF-1 in Cancer Progression: Novel Insights. A Review. 30411685

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The unique ability of PIM inhibitors to concomitantly target HIF1 and selectively kill hypoxic tumor cells addresses two major components of tumor progression and therapeutic resistance.<i></i>. 29084916

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE HIF 1α siRNA down-regulated the HIF 1α level, which was induced by the common hypoxic tumor environment or the ROS (generated by PDT), enhanced the PDT efficacy and partly inhibited the tumor progression. 30346453

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Because hypoxia and aneuploidy are both barriers to tumor progression, the ability of Hif-1α to promote cell survival following chromosome missegregation raises the possibility that aneuploidy tolerance coevolves with adaptation to hypoxia. 30332653

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE HIF-1α and mTOR are involved in the formation of local tumor progression and distant metastasis. 29695399

2018