Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Hyaluronan (HA), one of the major ECM (extracellular matrix) components have been identified as a physiological ligand for surface CD44 isoforms which are frequently overexpressed in malignant tumor cells during cancer progression. 31293964

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE CD44/MyD88 co-expression was associated with tumor progression, metastasis, and recurrence in advanced EOC, and an independent prognostic factor for disease-free survival and overall survival. 31019941

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE CD44 is an adhesion protein involved in tumour progression, metastasis and stemness in different cancers; however, there has been controversies about the significance of CD44 expression in neuroblastoma and its relationship with tumour progression. 31685444

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The cell membrane receptor CD44 is associated with cancer progression and has been recognized as a cancer stem cell marker including ovarian cancer, becoming a suitable candidate to be targeted by gPTX-L therapy. 30818864

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The biology and role of CD44 in cancer progression: therapeutic implications. 29747682

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Cluster of differentiation 44 (CD44) is a receptor for hyaluronic acid (HA) and HA-binding has been proven to participate in various biological tumor activities, including tumor progression, metastasis and drug resistance. 30504723

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression. 30211160

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE CD44 is overexpressed and correlated with tumor progression in gallbladder cancer. 30288117

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes. 29243496

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Various CD44 isoforms are expressed in several cancer stem cells during tumor progression and metastasis. 30402042

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Higher expression of CD44 in the tumor periphery than in the core was correlated with a highly invasive feature on MRI and was associated with early tumor progression and worse survival, whereas lower expression of CD44 in the tumor periphery corresponded to low invasion and was associated with longer survival. 30210550

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Ectopic expression of KLF4 increased the sphere formation ability and CD44/133-positive cell numbers, which can be reversed by abundant expression of miR-124, suggesting that KLF4 is a functional target of miR-124 in tumourigenesis and cancer progression of HCC. 29252002

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Overexpression of variant isoforms of CD44 (CD44v) is most commonly linked to cancer progression, whereas their loss is associated with inhibition of tumor growth. 27746219

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. 27993894

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In conclusion, our findings revealed that EMP3 might be a potential target for CD44-high GBMs and highlight the essential functions of EMP3 in TGF-β/Smad2/3 signaling activation and tumor progression. 27527869

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The overexpression of CD44 in cancer cells reroutes number of oncogenic pathways including the central Pi3K/Akt/NF-kB pathway leading to cancer progression and malignancy. 27989859

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE We defined a parameter CD44/CD24 ratio to present the expression level of CD44 and CD24 and found that high CD44/CD24 ratio and ALDH1<sup>+</sup> are both indicators for cancer malignancy, but play different functions during tumor progression. 29062075

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These results suggest that CD44 and CD90 may be important markers of tumor progression in NSCLC. 28499650

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The binding inhibitory activity of Tα1 on HA-CD44 or HA-RHAMM interactions can suppress both T-cell reactivity and tumor progression. 29077041

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hyaluronan (HA), an important glycosaminoglycan component of the extracellular matrix (ECM), and its major cell surface receptor, CD44, have been suggested to be important cellular mediators influencing tumor progression and treatment resistance in head and neck cancer. 28837080

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE CD44, a multifunctional surface receptor has been implicated in tumor progression in different cancers including MPM. 28403901

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE While several studies link the cell-surface marker CD44 to cancer progression, conflicting results show both positive and negative correlations with increased CD44 levels. 28052252

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE CD44, a transmembrane receptor, is expressed in the standard or variant form and plays a critical role in tumor progression and metastasis. 27178239

2016

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This new knowledge could provide the groundwork necessary for establishing new tumor markers and developing important, novel drugs targeted against HA/CD44-associated tumor progression, which can be utilized in the therapeutic treatment of metastatic cancer patients. 27070574

2016

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Additional subsets of CTCs within individual patients were characterized by divergent expression of genes involved in epithelial-mesenchymal transition (e.g., CDH2, MMPs, VIM, or ZEB1 and 2), DNA repair (RAD51), resistance to cancer therapy (e.g., AR, AR-V7, ERBB2, EGFR), cancer stemness (e.g., CD24 and CD44), activated signaling pathways involved in tumor progression (e.g., PIK3CA and MTOR) or cross talks between tumors and immune cells (e.g., CCL4, CXCL2, CXCL9, IL15, IL1B, or IL8). 27630154

2016