Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 GeneticVariation BEFREE In order to explore its potential attributing factors, we pooled the updated literatures to evaluate the association between NR5A2 polymorphism and the risk of pancreatic cancer in this meta-analysis. 29785120

2018

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 GeneticVariation BEFREE In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. 28639428

2018

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 AlteredExpression BEFREE This study aims to demonstrate expression and potential role of NR5A2 in pancreatic cancer. 27996162

2017

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 GeneticVariation BEFREE Our case-control study found that rs3790843 and rs3790844 in the NR5A2 gene are associated with pancreatic cancer risk in Japanese subjects. 26592175

2015

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 Biomarker BEFREE These observations demonstrate that LRH1 promotes PC growth and angiogenesis, suggesting that LRH1 is a driving factor in tumorigenesis and may serve as a potential therapeutic target. 24333731

2014

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 AlteredExpression BEFREE It was found that LRH1 enhanced transcriptional activity of β-catenin and the expression of downstream target genes (c-Myc, MMP2/9), as well as promoted migration, wound healing, invasion, and sphere formation of PC cell lines. 24769073

2014

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 GeneticVariation BEFREE Three NR5A2 variants that were previously identified in a genome-wide association study were significantly associated with reduced risk of pancreatic cancer, AORs ranging from 0.57 to 0.79. 21357378

2011

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 Biomarker BEFREE This study demonstrates the critical involvement of LRH-1 in development and progression of pancreatic cancer, suggesting the LRH-1 receptor as a plausible therapeutic target for treatment of pancreatic ductal adenocarcinomas. 21949357

2011

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk. 22125638

2011

Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.200 GeneticVariation BEFREE The associations of the ABO blood group gene and NR5A2 gene variants with PC discovered by recent genome-wide association studies may link insulin resistance, inflammation, and thrombosis to pancreatic carcinogenesis. 20647474

2010