Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 Biomarker BEFREE Given the lack of effective treatment strategies for pancreatic cancer, it is important to understand the functional implications of APC loss in pancreatic cancer cell lines. 31540078

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 AlteredExpression BEFREE APC protein expression in pancreatic cancer was validated by qRT-PCR and Western blot. 31391772

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 GeneticVariation BEFREE In the index patient a germline mutation both in the APC and BRCA2 gene was identified while one affected brother showed the BRCA2 mutation only and another brother is supposed to have developed pancreatic cancer due to multiple non-genetic risk factors. 27838800

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 AlteredExpression BEFREE Results of nested MSP demonstrated GLI1 expression affected the DNA methylation level of APC but not hMLH1 in PC. 22110720

2011

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 Biomarker BEFREE Most of the genes listed are responsible for various well-defined cancer syndromes, such as CDKN2A (familial atypical mole-multiple melanoma, FAMMM), the mismatch repair genes (Lynch Syndrome), TP53 (Li-Fraumeni syndrome), APC (familial adenomatous polyposis), and BRCA2 (breast-ovarian familial cancer), where PC is part of the cancer spectrum of the disease. 19150414

2009

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 GeneticVariation BEFREE Frequently reported genome alterations were: the +3q27 and +8q24 mutations of TP53 for esophageal cancer; +20q13 for gastric cancer; -18q22 and +20q12-q13 mutations of APC, TP53 and KRAS for colorectal cancer, and the -18q22 mutation of KRAS and TP53 for pancreatic cancer. 19023234

2008

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 GeneticVariation BEFREE This article traces the historical aspects of hereditary cancer dealing with identification and ultimate molecular genetic confirmation of commonly occurring cancers, particularly of the colon in the case of familial adenomatous polyposis and its attenuated form, both due to the APC germline mutation; the Lynch syndrome due to mutations in mismatch repair genes, the most common of which were found to be MSH2, MLH1, and MSH6 germline mutations; the hereditary breast-ovarian cancer syndrome with BRCA1 and BRCA2 germline mutations; the Li-Fraumeni (SBLA) syndrome due to the p53 mutation; and the familial atypical multiple mole melanoma in association with pancreatic cancer due to the CDKN2A (p16) germline mutation. 15264268

2004

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 Biomarker BEFREE Our results suggest that there are distinct differences in the molecular pathogenesis of gastric and pancreatic cancer and that abnormalities of APC and MCC may be involved particularly in the diffuse type of gastric cancer. 8406987

1993

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.390 GeneticVariation BEFREE Frequent somatic mutations of the APC gene in human pancreatic cancer. 1423316

1992