Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer. 31402126

2020

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively). 29993116

2018

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer. 29416783

2018

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6). 29110844

2017

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE In GWAS, a nicotine receptor locus(CHRNA3, previously associated with increased smoking and lung cancer) was associated with fathers' survival. 27015805

2016

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis. 26831765

2016

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. 26689306

2016

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Using a case-control study, we decided to investigate the associations between CHRNA3 rs6495308, CHRNB4 rs11072768, smoking behaviors and lung cancer risk, as well as explore whether the two SNPs have a direct or indirect carcinogenic effect on lung cancer. 26942719

2016

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers. 27072204

2016

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Single-nucleotide polymorphisms (SNPs) in the cholinergic nicotinic receptor subunit genes on chromosome 15q25.1, including CHRNA3, CHRNB4 and CHRNA5, are well-established biomarkers of chronic obstructive pulmonary disease (COPD) and lung cancer. 27462996

2016

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE The aim of this study was to identify whether CHRNA3 polymorphisms increase lung cancer risk directly or indirectly through smoking behavior in the Chinese Han individuals. 25656608

2015

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking. 25072098

2014

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese. 25288178

2014

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. 24186853

2013

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer. 23143843

2013

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n = 860). 23591849

2013

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE CHRNA3 variant for lung cancer is associated with chronic obstructive pulmonary disease in Korea. 23207642

2013

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE In conclusion, our results showed that several of the polymorphisms and their haplotypes in CHRNA5/CHRNA3 genes may have functional effects on (i) CHRNA5 mRNA levels, (ii) polycyclic aromatic hydrocarbon-DNA adduct levels, (iii) TP53 mutations and (iv) susceptibility to lung cancer. 23011884

2013

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. 23056235

2012

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in CHRNA3 rs3743073 (A>G) were determined using the TaqMan-MGB probe technique in 600 lung cancer cases and 600 normal controls. 23023782

2012

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE The CHRNA5-CHRNA3-CHRNB4 gene cluster on 15q25 has consistently been associated with smoking quantity, nicotine dependence and lung cancer. 23029550

2012

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Genetic factors included six variants implicated in a previous a genome-wide association study (GWAS) of NPC and three variants residing near the CHRNA3 and TERT genes that were linked to lung cancer risk in Asian populations. 23085811

2012

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Previous studies revealed association of lung cancer risk with single nucleotide polymorphisms (SNPs) in chromosome 15q25 region containing CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor (nAChR) subunit gene cluster. 22280835

2012

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Scope of Proposed Topic (50 words): Genome-wide association (GWA) studies both in lung cancer and COPD highlighted the same variants (SNPs) on the gene cluster CHRNA3-CHRNB4-CHRNA5. 23061658

2012

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians. 22701590

2012