Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE BRAF- and MEK-targeted therapies are effective in BRAF V600E/K metastatic melanoma and lung cancers; however, responses are short-lived due to emergence of resistance. 31744895

2020

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers. 30831205

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer. 30224342

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells. 31711466

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE BRAF mutations are found in 1-5% of non-small cell lung cancers, particularly adenocarcinomas. 31440061

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Economic analysis of BRAF gene mutation testing in real world practice using claims data: costs of single gene versus panel tests in patients with lung cancer. 29516752

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Accordingly, the combination of MEK inhibitor with EGFR inhibitor was effective at shrinking tumors in mouse model of BRAF non-V600E mutant lung cancer. 29348459

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE These results indicate that AZ628 has greater potential than Dabrafenib, both as a single agent and combined with Trametinib, for the treatment of non-V600 BRAF mutant lung cancer. 29662630

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE A group of thoracic oncology experts in the field of thoracic oncology met to describe the standard for biomarker testing for lung cancer in the Canadian context, focusing on evidence-based recommendations for standard-of-care testing for <i>EGFR</i>, anaplastic lymphoma kinase (<i>ALK</i>), <i>ROS1</i>, <i>BRAF V600</i> and programmed death-ligand (PD-L1) at the time of diagnosis of advanced disease and <i>EGFR T790M</i> upon progression. 29507487

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE A CARP-1 functional mimetic compound is synergistic with BRAF-targeting in non-small cell lung cancers. 30038713

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE BRAF Mutant Lung Cancer: Programmed Death Ligand 1 Expression, Tumor Mutational Burden, Microsatellite Instability Status, and Response to Immune Check-Point Inhibitors. 29723688

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation. 28012356

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Therapeutic approach to treating patients with BRAF-mutant lung cancer: latest evidence and clinical implications. 28203297

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC). 28625649

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE This study provides a basis for the clinical exploration of non-V600 BRAF mutant lung cancers upon treatment with Trametinib and Dabrafenib. 28947956

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE ATM loss also enhances the sensitivity of KRAS- or BRAF-mutant lung cancer cells to MEK inhibition. 27922010

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE BRAF fusions included 3% (14/531) of melanomas; 2% (15/701) of gliomas; 1.0% (3/294) of thyroid cancers; 0.3% (3/1,062) pancreatic carcinomas; 0.2% (8/4,013) nonsmall-cell lung cancers and 0.2% (4/2,154) of colorectal cancers, and were enriched in pilocytic (30%) vs. nonpilocytic gliomas (1%; p < 0.0001), Spitzoid (75%) vs. nonSpitzoid melanomas (1%; p = 0.0001), acinar (67%) vs. nonacinar pancreatic cancers (<1%; p < 0.0001) and papillary (3%) vs. nonpapillary thyroid cancers (0%; p < 0.03). 26314551

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE One of our predicted biomarker pairs, a mutation in the BRAF gene and upregulated expression of the PIM1 gene, was experimentally validated to benefit from a therapy combining BRAF inhibitor and PIM1 inhibitor in lung cancer. 26916442

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. 27834212

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Our clinical data suggest that BRAF mutations define specific subsets of patients with NSCLC; while their oncogenic nature is yet to be established in lung cancer, especially for non-V600E mutations, the value of BRAF mutations to predict the efficacy of targeted agents remains unclear. 26711930

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The three most common BRAF mutations in lung cancers accounted for only 41% of the observed BRAF mutations (p.D594G [18%], p.V600E [14%], and p.G469A [9%]). 26386083

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Jointly, our results suggest a potential role of the novel BRAF fusion in lung cancer development and therapy. 25985019

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE We developed a highly sensitive LUNG CANCER (LC)-biochip approach for the detection of the most common EGFR, KRAS, PIK3CA, and BRAF gene mutations. 25153497

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE BRAF mutants with impaired or unknown kinase activity as well as concomitant kinase-impaired BRAF mutations and RAS mutations were detected in lung cancers, colorectal cancers and melanomas. 26498038

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 AlteredExpression BEFREE Recent evidence shows that BRAF-activated non-coding RNA (BANCR) acts as a critical role in the proliferation and metastasis in malignant melanoma and lung cancer; however, little is known about the significance of lncRNA BANCR in retinoblastoma. 25894373

2015