Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Mechanistically, we uncovered that autophagy was induced upon loss of <i>circHIPK3</i> via the <i>MIR124-3p</i>-STAT3-PRKAA/AMPKa axis in STK11 mutant lung cancer cell lines (A549 and H838). 31232177

2020

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE We developed a mouse model for <i>Lkb1</i>-deficient lung cancer with conditional deletion of essential autophagy gene <i>Atg7</i> to test whether autophagy compensates for LKB1 loss for tumor cells to survive energy crises. 30692209

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss. 30825612

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 AlteredExpression BEFREE Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells. 31333780

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Co-occurring genomic alterations, particularly in tumour suppressor genes such as TP53 and LKB1 (also known as STK11), have emerged as core determinants of the molecular and clinical heterogeneity of oncogene-driven lung cancer subgroups through their effects on both tumour cell-intrinsic and non-cell-autonomous cancer hallmarks. 31406302

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers. 30626603

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Inactivated mutations of LKB1, observed in 20-30% of nonsmall cell lung cancers (NSCLC), contribute significantly to lung cancer malignancy progression. 31217475

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE The aim of this review is to discuss interactions of LKB1 with the tumor microenvironment and the potential applications of this knowledge in predicting response to treatment in lung cancer. 30995715

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE In vivo study also showed that Shh signaling pathway was involved in the modulation of LKB1 on the metastasis and angiogenesis of lung cancer. 30784288

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. 31285420

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE SIGNIFICANCE: Oncogenic <i>KRAS</i>-mutant lung cancers remain treatment-refractory and are resistant to ICB in the setting of LKB1 loss. 30297358

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Although loss-of-function mutations involving the tumor suppressor gene, <i><i>STK11</i> (LKB1)</i> are important in lung cancer progression, <i> 31697874

2019

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Targeted therapies for LKB1-inactivated lung cancer are currently unavailable. 30423141

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Our in vivo study also showed that LKB1 inhibited lung cancer growth in vivo and modulated Shh signaling pathway. 29573522

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Our study provides insight into the molecular mechanism by which GDH1-mediated metabolic reprogramming of glutaminolysis mediates lung cancer metastasis and offers a therapeutic strategy for patients with LKB1-deficient lung cancer. 29249655

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. 29963200

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Moreover, mutations and misregulation of LKB1 have been reported to occur in most types of tumors and are among the most common aberrations in lung cancer. 29540834

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts. 30297789

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Liver kinase B1 (LKB1) as a tumor suppression gene that is associated with various kinds of cancers, including lung cancer. 30033530

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 AlteredExpression BEFREE PLAG1-mediated GDH1 upregulation promotes LKB1-deficient lung cancer anoikis resistance. 29305497

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE In addition, exosomes isolated from H460 cells with stable restoration of LKB1 had much higher ability in stimulating lung cancer cell migration than did those from H460 cells lacking LKB1. 29138862

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE We used a mouse lung cancer model with metastasis driven by conditionally activated Kras and concurrent tumor suppressor Lkb1 loss (Kras<sup>G12D</sup>/ Lkb1<sup>-/-</sup> model) and a similar model of lung cancer that does not metastasize, driven by conditionally activated Kras alone (Kras<sup>G12D</sup> model). 29909489

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Further, CP alone or in combination with rapamycin strongly inhibited the in vitro and in vivo growth of tumors harboring mutations in KEAP1 or both KEAP1 and LKB1 that are frequently observed in lung cancer. 28504720

2017

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 AlteredExpression BEFREE Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. 28598439

2017

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE Our study also provides new evidence to support the critical role of liver kinase B1 in the pathogenesis of human papillomavirus-related lung cancer and suggests novel therapeutic targets. 28720067

2017