Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE Genome-wide significant associations were observed with 84 variants all located at the known PrCa risk regions at 8q24 (128.484-128.548) and 10q11.22 (MSMB gene). 31226226

2020

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Additionally, 6 pathways were identified based on identified variants and genes, including estrogen signaling pathway, signaling by MST1, IL-15 production, MSP-RON signaling pathway, and IL-12 signaling and production in macrophages, which are known to be associated with prostate cancer. 31748686

2019

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Plasma MSP concentrations were inversely associated with prostate cancer risk after adjusting for total prostate-specific antigen concentration [odds ratio (OR) highest versus lowest fourth of MSP = 0.65, 95% confidence interval (CI) 0.51-0.84, Ptrend = 0.001]. 31089709

2019

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. 30774776

2019

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE A total of 31 proteins were associated with prostate cancer risk including proteins encoded by <i>GSTP1</i>, whose methylation level was shown previously to be associated with prostate cancer risk, and <i>MSMB, SPINT2, IGF2R</i>, and <i>CTSS</i>, which were previously implicated as potential target genes of prostate cancer risk variants identified in genome-wide association studies. 31337649

2019

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer. 31516752

2019

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE Our data revealed that the T allele of MSMB rs10993994 polymorphism was significantly associated with PCa in all subjects (allele contrast: OR=1.24, 95% CI=1.19-1.29, p<0.001). 31773691

2019

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE MSMB levels are also reduced in the circulation and MSMB is therefore used as a serum biomarker for prostate cancer. 29250809

2018

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE We also review the diagnostic assays that are developed for PSP94 for use in the diagnosis of PCa and use of such tests in the differential diagnosis of PCa from benign prostatic hyperplasia (BPH). 28930560

2018

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Our data also demonstrated that HGF/c-Met, but not the MSP-RON signaling pathway may be the dominant mechanism for PCa EMT. 28440432

2017

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE We assessed the performance of a 4-kallikrein panel with and without microseminoprotein-β to predict high grade (Gleason 7+/Gleason Grade Group 2+) prostate cancer on biopsy in a multiethnic cohort from PLCO (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial). 27810449

2017

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE In conclusion, this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC. 28212531

2017

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Our objective was to determine the gene expression pattern of the SFRP family in prostatic cell lines and fresh frozen tissues from normal prostates (NP), benign prostatic hyperplasia (BPH) and prostate cancer (PCa), by qRT-PCR, and their DNAme status by MSP and bisulfite sequencing. 27570179

2016

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Across 66 meta-analyses, a total of 20 genetic variants involving 584,100 subjects in 19 different genes (KLK3, IGFBP3, ESR1, SOD2, CAT, CYP1B1, VDR, RFX6, HNF1B, SRD5A2, FGFR4, LEP, HOXB13, FAS, FOXP4, SLC22A3, LMTK2, EHBP1 and MSMB) exhibited significant association with prostate cancer. 26967244

2016

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE In this report, individual domains of prostate cancer related biomarkers; MSMB and PSA were overexpressed in bacterial system and purified in their folded forms using affinity chromatography. 27038170

2016

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE The methylation of GSTP1 and RASSF1A was investigated by using the MSP in 50 prostate cancer and 17 benign prostate hyperplasia specimens. 25577235

2015

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE A peak at m/z 10,760 was identified as β-microseminoprotein (β-MSMB) and found to be statistically lower in urine from PCa participants using the peak's average areas. 24115268

2014

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Another novel mechanism, which we propose in this review article, is that PSP94 may protect against prostate cancer by preventing or limiting an intracellular fungal infection in the prostate. 24464504

2014

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker BEFREE Comparison of prostate-specific promoters and the use of PSP-driven virotherapy for prostate cancer. 23484134

2013

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here. 22887727

2013

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. 23608167

2013

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 AlteredExpression BEFREE Quantitative RT-PCR analysis revealed that MSMB, NBL1 and AZGP1 were expressed with much higher specificity in PCa and NP than in 14 other kinds of normal tissue. 22948749

2013

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer. 23213189

2013

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and PCa risk. 24037734

2013

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 GeneticVariation BEFREE Variants in the promoter of the MSMB gene have been associated with the risk of prostate cancer (PCa) in several independent genome-wide association studies. 22661295

2012