Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Therefore, we tested whether a similar preparation might reduce tumorigenesis in the colon of Pirc rats (F344/NTac-Apc) mutated in the Apc gene and thus, like familial adenomatous polyposis patients, spontaneously developing multiple tumors in the colon. 31651566

2020

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE GSEA demonstrated a strong association between duodenal adenoma/adenocarcinomas with colorectal adenomas (p < 10<sup>-5</sup>) and gene expression patterns seen after APC gene knockout (p < 10<sup>-5</sup>), suggesting that the Wnt/β-catenin pathway plays a crucial role in the carcinogenesis of these neoplasms. 29951927

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The CXCR7/CXCR4 heterodimerization also promoted APC mutation-driven colorectal tumorigenesis in APC<sup>Min/+</sup>/villin-CXCR7-CXCR4 mice. 30337690

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In contrast, intestinal tumorigenesis was not suppressed by Stat3 disruption in adenomatous polyposis coli ( Apc) <sup>Δ716</sup> and Apc<sup>∆716</sup> Tgfbr2<sup>∆IEC</sup> mice, thus indicating that Stat3 is not required for Wnt activation-driven intestinal tumorigenesis. 30156908

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Mutations in adenomatous polyposis coli (APC) gene play a pivotal role in adenoma-carcinoma pathway of colorectal tumorigenesis. 28253712

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Genetic deletion of the IL-1 receptor (IL-1R1) in epithelial cells alleviated tumorigenesis in the APC model of CRC, demonstrating a cell-autonomous role for IL-1 signaling in early tumor seed outgrowth. 30650375

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Our results demonstrated that metabolites alterations in FAP can be helpful for further analysis of metabonomics induced by APC mutation, and these alterations might be involved in the progress of intestinal carcinogenesis. 30983515

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In the current study, we found that NHP inhibited colorectal tumorigenesis in the APC <sup>min/+</sup> transgenic mouse model, as well as induced apoptosis and blocked angiogenesis in vivo. 31560944

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE But the age of carcinogenesis for patients with both APC and MUTYH mutations was later than APC mutation carriers and similar to MUTYH mutation carriers. 31062380

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In contrast to this well-established role of APC, recent studies from our laboratory demonstrated that APC functions through Wnt-independent pathways to mediate in vitro and in vivo models of breast tumorigenesis. 31540078

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Hereditary polyposis syndromes in which APC gene germline mutations can lead to colorectal carcinogenesis are familial adenomatous polyposis (FAP), attenuated FAP (AFAP) and MUTYH-associated polyposis. 30836352

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In this study, we investigated the effects of pentoxifylline on inflammation-related colon tumorigenesis in a rodent model using Kyoto APC delta rats, which have APC mutation and are susceptible to colon carcinogenesis. 30338039

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE We conclude that increased WNT signaling is important in the transition to malignancy in the serrated pathway but that APC mutation is less common and the spectrum of mutations is different than in conventional colorectal carcinogenesis. 29148535

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. 29275959

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE The study aims to provide deeper insights into the discovery, identification and functional pathways analysis of differentially expressed metabolites in intestinal tumorigenesis in APC <sup>min/+</sup> mice used by the serum metabolomics, and bring about useful information for further effective prevention and treatment of the disease. 30316137

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE <i>β</i>-catenin is confirmed as a major driver of colorectal carcinogenesis but is controlled by many more players other than APC. 30186819

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The Apc<sup>Min/+</sup> mouse, carrying an inactivated allele of the adenomatous polyposis coli (Apc) gene, is a widely used animal model of human colorectal tumorigenesis. 30243094

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Based on published and our data we propose that K-ras could be the oncogene responsible for the inactivation of the tumor-suppressor gene APC, currently considered as the initial step in colorectal tumorigenesis. 28652417

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The mutation of APC (rs137854573, c.C1606T, rs137854573" genes_norm="324">p.R536X) could result in HB carcinogenesis by activating Wnt signaling. 30619485

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In conclusion, we have developed a novel iPSC/intestinal model of APC mutagenesis and provide strong evidence that APC in heterozygosity imparts a clear phenotypic and molecular defect, affecting basic cellular functions and integrity, providing novel insights in the earlier events of APC-mediated tumorigenesis. 30024920

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Our findings therefore reveal a reciprocal suppression mechanism between FZR1 and BRAF in controlling tumorigenesis.<b>Significance:</b> FZR1 inhibits BRAF oncogenic functions via both APC-dependent proteolysis and APC-independent disruption of BRAF dimers, whereas hyperactivated ERK and CDK4 reciprocally suppress APC<sup>FZR1</sup> E3 ligase activity. 28174173

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This novel Wnt-driven mammary tumor model highlights the importance of functional redundancies existing between the Apc proteins both in normal homeostasis and in tumorigenesis. 27694902

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Together, our results suggest that the high-risk Western diet primes the intestine to tumorigenesis through synergistic effects in energy metabolism, inflammation and oxidative stress, which culminate in the acceleration of LOH of the Apc gene. 27833053

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE The results indicate that APC promoter hypermethylation is an early event in carcinogenesis of CRC, could be a valuable diagnostic marker for early-stage CRC. 28515349

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE The proportion of APC promoter 1A methylation in lung cancer tissues was higher than in autologous controls, indicating that promoter 1A methylation of the APC gene may play an important role in NSCLC carcinogenesis. 28497891

2017