Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Overexpression of MDM2 oncoprotein has been detected in a large number of diverse human malignancies and has been shown to play both p53-dependent and p53-independent roles in oncogenesis. 31706019

2020

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We found that CPHSP, a novel spirooxindole-pyrrolizidine derivative, can target the MDM2/p53 signaling that is essential for the tumorigenesis of hepatocellular carcinoma (HCC). 31425749

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This investigation elucidated the mechanism of how MDM2 promotes genome instability and enhances tumorigenesis in the absence of p53, thus providing a theoretical and experimental basis for targeting MDM2 as a cancer therapy. 30816344

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE In vitro functional experiments revealed that the co-overexpression of MDM2 and CDK4 plays a key role in tumorigenesis by increasing cell growth and migration and inhibiting adipogenic differentiation potency when compared with the sole expression of MDM2 or CDK4. 31160689

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MDM2-C may have a positive or negative role in breast tumorigenesis depending on mtp53 expression. 30470976

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Our results not only broaden the range of specific substrates of MDM2 beyond the cell cycle to include circadian components but also identify a previously unknown regulator of the clock as a druggable node that is often found to be deregulated during tumorigenesis. 30425162

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE HOXA13 played a role of carcinogenesis through directly down-regulating DHRS2 to increase MDM2. 29436749

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These results reveal that YY1-CDKN3-MDM2/P53-P21 axis is involved in pancreatic tumorigenesis, which may develop new methods for human pancreatic cancer therapy. 29168185

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Our data provide evidence that constitutive MDM2-ALT1 expression is itself an oncogenic lesion that aggravates the tumorigenesis induced by p53 loss. 28892044

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Accumulating evidence indicates that the MDM2 oncoprotein promotes tumorigenesis beyond its canonical negative effects on the p53 tumor suppressor, but these p53-independent functions remain poorly understood. 29452639

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2-p53 interaction. 30259932

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Proper function of the murine double minute 2 (MDM2)-p53 axis is known to prevent tumorigenesis and several metabolic diseases, yet its role in regulation of adipose tissue aging is still poorly understood. 30131393

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14<sup>ARF</sup>-Mdm2-P53-dependent cellular senescence. 30464807

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE This study showed that p16 and MDM2 polymorphisms do not play a decisive role in tumorigenesis, but some genotypes of these polymorphisms might be associated with follow-up characteristics of prolactinoma. 28438863

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. 29547122

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Overexpression of MDM2 drives breast oncogenesis in the presence of wild-type or mutant p53 (mtp53). 28615518

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These data establish that the RP-MDM2-p53 pathway, in contrast to the p19ARF-MDM2-p53 pathway, is a critical mediator of colorectal tumorigenesis following APC loss. 27617574

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In conclusion, we report here a novel mechanism for how sustained activation of PERK axis of ER-stress during chronic HCV infection activates oncogenic Nrf2 signaling that promotes hepatocyte survival and oncogenesis by inducing Mdm2-mediated Rb degradation. 28835697

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. 27856536

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE RPL5 and RPL11 prevent tumorigenesis by binding to and inhibiting the MDM2 ubiquitin ligase and thereby up-regulating p53. 28722511

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE It is well recognized that murine double minute gene 2 (MDM2) plays a critical role in cell proliferation and inflammatory processes during tumorigenesis. 28100501

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE In a word, via increasing hnRNPA1 level and then reducing the expression of MDM2, estradiol prevented carcinogenesis in melanomas. 28035066

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE These findings indicate that high-level MDM2 expression is needed in order to perform a critical p53-independent function and may obviate the need for genomic alterations to the p53 pathway during retinoblastoma tumorigenesis. 27748758

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Indeed, a large body of work has shown that dysregulation of p53 and its E3 ligase MDM2 by the ubiquitin-proteasome system (UPS) promotes carcinogenesis and malignant transformation. 28587923

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE LRP6 targeting suppresses gastric tumorigenesis via P14<sup>ARF</sup>-Mdm2-P53-dependent cellular senescence. 29340077

2017