Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 PosttranslationalModification BEFREE Our results support the conclusion that C/EBPβ down-regulated ERβ expression through increasing its promoter methylation, and then regulated proliferation and apoptosis in PCa. 29322786

2019

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE Higher levels of ZFHX3 and ERβ in human prostate cancer tissue samples correlated with better patient survival. 30979864

2019

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE In the present study, the role of ERβ in lipopolysaccharide (LPS)‑induced inflammation and association with NF‑κB activity were investigated in PC‑3 and DU145 prostate cancer cell lines. 30864712

2019

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Taken together, our data demonstrated that bakuchiol inactivated NF-κB signaling via AR and ERβ, which contributes to inhibition of PC-3 cell proliferation and migration, indicating that bakuchiol is one of the key component from P. corylifolia L for PCa treatment and has a potential as anti-prostate cancer drug candidates. 30236540

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. 30326857

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE The analysis of several immortalized cell lines derived from freshly explants of prostate cancer specimens showed that Nup153 protein was higher and present in multimeric complexes with eNOS and ERβ as compared to normal/hyperplastic prostate epithelial cells. 29963256

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE The expression of estrogen receptor (ER)-β appears to be lost during prostate cancer progression through hypermethylation mechanism. 29455003

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE In addition, ARs; estrogen receptors (ERs; ERα and ERβ); and estrogen-related receptors (ERRs; ERRα, ERRβ, and ERRγ) have been reported to be involved in the development or regulation of PC. 29360794

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Moreover, distinct ERβ dynamics in various cellular bio-settings such as prostate cancer (DU-145) or triple-negative breast cancer (MDA-MB-231) cells were directly observed for the first time viaFPNM staining. 29610818

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE Additionally, FTY720 abolished estrogen-stimulated expression of ERα and basal expression of ERβ within prostate cancer cells. 29654831

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE Estrogen receptor beta (ERβ) splice variants are implicated in prostate cancer (PC) progression; however their underlying mechanisms remain elusive. 28968951

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE In addition, transfection experiment of ERβ-siRNA further indicated that diosicn showed excellent activity against PCa in vitro and in vivo by increasing ERβ expression level. 28796245

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Considering a combination marker panel of MCAM, ERα and ERβ increased the sensitivity to 75% and the specificity became 70% for the minimally invasive early detection test of PC. 28147335

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE ERβ is commonly studied in MCF-7 (breast) and LNCaP (prostate) cancer cell lines, but we found no ERβ expression in either, using validated antibodies and independent mass spectrometry-based approaches. 27889472

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Although it is speculated that ERα is associated with harmful effects on PCa, the role of ERβ in PCa is still ill-defined. 28503095

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Involvement of estrogen receptor β in androgen receptor-induced growth inhibition in prostate cancer PC-3 cells. 28928821

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE Taken together, our results support the conclusion that abnormal methylation of the ERβ promoter may increase genetic susceptibility to prostate cancer. 26547439

2016

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE It potently and selectively inhibited cell proliferation of prostate cancer (PC3/DU145) cells in comparison to normal (non-cancer) cells by promoting cell-cycle arrest and apoptosis, accompanied with inhibition of total DNMT activity, and re-expression of ER-β (mRNA/protein). 26599461

2016

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Although, an increasing body of evidence has linked estrogen receptor beta (ERß) to prostate cancer, the function of estrogen receptor alpha (ERα) in prostate cancer is not very well studied. 26575018

2015

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE This finding provides a mechanism for how ERβ expression is regulated in prostate cancer. 25818291

2015

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10(-8); PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10(-10); ESR2). 26443449

2015

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Clinical significance of estrogen receptor β in breast and prostate cancer from biological aspects. 25611678

2015

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE These findings provide a novel mechanism for how ERβ prevents NF-κB activation and raise the exciting possibility that loss of ERβ expression is linked to chronic inflammation in the prostate, which contributes to the development of high-grade prostate cancer. 26450901

2015

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE ERβ is epigenetically silenced in prostate cancer patients, therefore our results suggest that combination of ERβ agonists with ADT would benefit men stratified on the basis of high estrogen levels. 25816367

2015

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE Genistein induced phosphorylation, nuclear translocation and transcriptional activity of ER-β in all three PCa cell lines. 25931004

2015