Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE Functional inactivation of GSTP1 increases the susceptibility to oxidative stress and enhance progression risk of the prostatic carcinoma. 31837464

2020

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE All biopsy cores from the negative index biopsy were profiled for the epigenetic biomarkers GSTP1, APC, and RASSF1 using ConfirmMDx for Prostate Cancer (MDxHealth, Irvine, CA). 29660369

2019

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 PosttranslationalModification BEFREE GSTP1 promoter methylation was highly correlated with the incidence of prostate cancer. 31263949

2019

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 PosttranslationalModification BEFREE GSTP1 methylation in the first and in the second negative biopsy was associated with prostate cancer detection [OR per 1% increase: 1.14 (95% CI 1.01-1.29) for the second biopsy and 1.21 (95% CI 1.07-1.37) for the highest methylation level (first or second biopsy)]. 31666119

2019

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Our study emphasizes the notion of a potential value of HIF-1α and c-myc as putative biomarkers in prostate cancer; moreover TCGA data analysis showed a putative crosstalk between c-myc, HIF-1α, ERG, TKT, and GSTP1, suggesting a potential use of this axis in prostate cancer. 30357756

2019

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE The androgen-receptor gene (AR-CAG) repeat length and the percentage of promoter methylation (PPM) of genes glutathione-S-transferase P1 (GSTP1) and Ras association domain family 1 isoform A (RASSF1A) improve PCa detection. 29571584

2018

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE We developed a Prostate Cancer Urinary Epigenetic (ProCUrE) assay based on an optimal two-gene (HOXD3 and GSTP1) LASSO model, derived from methylation values in the training cohort, and assessed ProCUrE's diagnostic and prognostic ability for prostate cancer in both the training and validation cohorts. 30470249

2018

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE For clinical application, the level as well as the concentration of methylation of glutathione-S transferase-P1 (GSTP1) and EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1), which are known to be closely associated with prostate cancer diagnosis, are electrochemically detected in human urine spiked with these genes. 29453167

2018

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Despite the large number of published papers and the promising results, GSTP1 has not yet entered the clinical practice even for PCa diagnosis. 29305565

2018

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Gene-based biomarkers in urine such as prostate cancer antigen-3 (PCA3), and genes for transmembrane protease serine-2 (TMPRSS2), and glutathione S-transferase P (GSTP1) have been developed and evaluated in the past decades. 28917266

2017

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE We focused on nine genes (AOX1, CCDC181 (C1orf114), GABRE, GAS6, HAPLN3, KLF8, MOB3B, SLC18A2, and GSTP1) known to be hypermethylated in PC. 28084441

2017

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE GSTP1 overexpression or MYC siRNA also decreased cell motility of PC via reducing the closing rate of scratch wounds and the number of invasive cells. 28653607

2017

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE The impacts of these alterations on disease development are unclear, but elevated GSTp1 promoter DNAm and subsequent gene inactivation has been consistently associated with prostate cancer.. 27996157

2017

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE The present study explores the effects of restored GSTP1 expression on glutathione levels, accumulation of oxidative DNA damage, and prostate cancer cell survival following oxidative stress induced by protracted, low dose rate ionizing radiation (LDR). 26447830

2016

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE We identified five highly methylated genes in prostate cancer: GSTP1, RARB, RASSF1, SCGB3A1, CCND2 (P < 0.0001), with an area under the ROC curve varying between 0.89 (95 % CI 0.82-0.97) and 0.95 (95 % CI 0.90-1.00). 27576364

2016

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE The progressive loss of GSTP1 expression from healthy glands to PIN and to PCa glands underlines its involvement in early carcinogenesis. 27594734

2016

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 PosttranslationalModification BEFREE We evaluated whether global hypomethylation, measured through LINE-1 methylation, and GSTP1 hypermethylation on a negative biopsy are associated with subsequent prostate cancer diagnosis. 26475336

2016

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 PosttranslationalModification BEFREE However, only GSTP1 methylation was significantly associated with CF in both independent high-risk PCa cohorts. 26086362

2015

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population with other regions in the country and different ethnic groups. 25251951

2015

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE Developing a methylation-specific dot blot assay (MSP-DB) to increase the sensitivity and specificity of simultaneous methylation analysis of multiple genes is the goal of the present study to evaluate the methylation status of GSTP1 and RASSF1A from prostate cancer in Vietnamese males. 25577235

2015

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE GSTP1 and APC were hypermethylated in the majority of PCa tissue samples. 25738352

2015

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer. 24610081

2014

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE Seventy percent of prostate cancer patients lose expression of transforming growth factor-beta type II receptor (TGFBR2) in the stromal compartment (n=77, P-value=0.0001), similar to the rate of glutathione S-transferase P1 (GSTP1) silencing. 24141771

2014

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE Additionally, human prostate carcinoma LNCaP cells, which contain a silenced GSTP1 gene, were genetically modified to constitutively express high levels of GSTP1. 22833520

2014

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 PosttranslationalModification BEFREE Greater GSTP1 promoter methylation in cancer tissue was independently associated with the risk of recurrence in patients with early prostate cancer. 24769028

2014