Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6). 29110844

2017

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent. 27072204

2016

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE Meta-analysis of the association between the rs8034191 polymorphism in AGPHD1 and lung cancer risk. 25854352

2015

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE Genetic association between AGPHD1 variant and lung cancer risk. 25074529

2014

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians. 22701590

2012

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE In a nested case-control study comparing 746 lung cancer cases to 1,477 controls, all of whom were non-Hispanic white smokers in the β-Carotene and Retinol Efficacy Trial, we examined whether lung cancer risk is associated with single nucleotide polymorphisms (SNPs) tagging the AGPHD1, CHRNA5, CHRNA3, and CHRNB4 genes and whether such risk is modified by diet and other characteristics. 21229299

2011

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 Biomarker BEFREE Three single nucleotide polymorphisms (SNPs) of CHRNA3, CHRNA5 and LOC123688 increase lung cancer risk. 19733931

2010

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 GeneticVariation BEFREE Associations of SNPs in LOC123688 (rs10519203; odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.25 to 2.05, P = .00016), CHRNA5 (rs2036527; OR = 1.67, 95% CI = 1.26 to 2.21, P = .00031), and CHRNA3 (rs1051730; OR = 1.81, 95% CI = 1.26 to 2.59, P = .00137) genes with lung cancer risk reached Bonferroni-corrected levels of statistical significance (all statistical tests were two-sided). 20554942

2010

Entrez Id: 123688
Gene Symbol: HYKK
HYKK
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.190 Biomarker BEFREE We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. 18780872

2008