Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4854
Gene Symbol: NOTCH3
NOTCH3
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 GeneticVariation BEFREE In conclusion, the rs3815188 variant and rs1043994 variant of the Notch3 gene is associated with lung cancer risk in patients of Turkish origin. 30806291

2019
Entrez Id: 4854
Gene Symbol: NOTCH3
NOTCH3
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 Biomarker BEFREE Notch3 was detected in human lung cancer cell lines and in tissues. 26838758

2016
Entrez Id: 4854
Gene Symbol: NOTCH3
NOTCH3
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression BEFREE In keeping with previous observations, we find that Notch3 in particular is upregulated in human lung cancer lines and that downregulation of Notch signaling using a selective γ-secretase inhibitor (MRK-003) is associated with decreased proliferation and clonogenic capacity in vitro. 21994468

2011
Entrez Id: 4854
Gene Symbol: NOTCH3
NOTCH3
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 Biomarker BEFREE These findings rationalize a mechanistic approach to lung cancer treatment based on Notch3 receptor-targeted therapeutic development. 20068176

2010
Entrez Id: 4854
Gene Symbol: NOTCH3
NOTCH3
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 Biomarker BEFREE Notch signaling has been shown to promote and maintain survival of many types of cancers, and we previously have shown that Notch3 plays an important role in lung cancer. 17804716

2007