Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. 31842975

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE A preventive potential of high calcium intake against colorectal cancer has been indicated for distal colon cancer, which is inversely associated with high-level CpG island methylator phenotype (CIMP), high-level microsatellite instability (MSI), and BRAF and PIK3CA mutations. 30963391

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE The kinetics of ctDNA derived from each cancer type were monitored targeting BRAF V600R (melanoma) and KRAS G13D (colon cancer), specifically reflected the status of the patient's tumours. 31727009

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Here we investigated whether combination of 5-FU and a MEK inhibitor had treatment sequence-dependent synergistic effects in KRAS or BRAF mutant colon cancer models. 30579838

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE The subgroup of colon cancer (CRC) characterized by mutation in the BRAF gene and high mutation rate in the genomic DNA sequence, known as the microsatellite instability (MSI) phenotype, accounts for roughly 10% of the patients and derives from polyps with a serrated morphology. 30623363

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE Moreover, tetrathiomolybdate treatment was also effective in reducing the clonogenic potential of colon cancer BRAF<sup>V600E</sup> cells resistant to BRAF pharmacological inhibition. 31083627

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE In the present study, it is demonstrated that KRAS and BRAF mutations induce anoikis resistance in colon cancer (Caco‑2) cells. 31545494

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Immunohistochemistry with Anti-BRAF V600E (VE1) Mouse Monoclonal Antibody is a Sensitive Method for Detection of the BRAF V600E Mutation in Colon Cancer: Evaluation of 120 Cases with and without KRAS Mutation and Literature Review. 29127628

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report. 31185985

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Our results highlight the need to evaluate the action of glucocorticoid on cancer progression in melanoma, thyroid and colon carcinoma in which B-RAF-V600E is a frequent oncogene, and cancers in which evasion from senescence has been shown. 31371485

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE A colon cancer cell line with RNF43-G659Vfs*41 and BRAF-V600E mutations was sensitive to activation of Wnt/β-catenin signaling. 31811196

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Serine/threonine kinase B-Raf proto-oncogene (BRAF) mutant colon cancer has a poor prognosis and there is an absence of targeted treatments for this subtype. 30396937

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Fisher's exact test showed that only two detected mutations at BRAF (V600E) and PIK3CA (E542K) were significantly positively correlated with right-sided colon cancer. 29556349

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE A higher average number of mutations were observed in right versus left colorectal cancer (P < .01), with 13 of 14 BRAF mutations located in right colon cancer. 29128266

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Colon carcinoma BRAF V600E HT29 cells exhibited poor response to radiation compared to BRAF wild-type COLO320 and HCT116 cells. 29663854

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE To determine the prognostic and predictive value of PTL according to BRAF, RAS, and MSI status in patients with stage III CC receiving adjuvant treatment with FOLFOX (folinic acid [leucovorin calcium], fluorouracil, and oxaliplatin) with or without cetuximab. 29167892

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE Although <i>BRAF</i>-directed treatments have yielded clinical benefit in a subset of tumor types, such as melanoma, thyroid cancer, and lung cancer, BRAF inhibition fails to confer a clinical benefit in colon cancer. 30181415

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE PTL does not seem to clearly influence disease-free survival (DFS) in localised colon cancer even though the opposite prognostic value of RS tumors on DFS depending on RAS/BRAF mutational status has been recently suggested in these patients. 29790124

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE Overall, the current study has identified activation of the Wnt/β-catenin pathway as a novel fundamental cause of colon cancer resistance to BRAF inhibition. 29167314

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Among patients with non-MSI-high cancer, BRAF mutation status emerged as a distinct marker with higher connectivity in the network of proximal colon cancer, but not in distal colorectal cancer. 28623901

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE The aim of this study was to investigate the influence of BRAF and KRAS mutation status on the association between aspirin use and overall survival after colon cancer diagnosis. 28125730

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE To date, identification of HER2 expression in gastric adenocarcinoma and KRAS, NRAS and BRAF mutations in colon cancer have proved essential for treatment decisions. 28067073

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE These findings illustrate the utility of non-invasive PET imaging measures of glutamine uptake to selectively predict response to BRAF-targeted therapy in colon cancer and may suggest further opportunities to inform colon cancer clinical trials using targeted therapies against MAPK activation. 27770401

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Activating BRAF mutations promote constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway and are common in a variety of human malignancies, including melanoma and colon cancer. 27321184

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Complex <b>1</b> has an outstanding inhibitory effect against BRAF-mutant colon carcinoma and hepatocarcinoma cell growth; <b>1</b> and <b>2</b> are both more active than the free ligand and have the capacity to trigger early apoptotic processes. 28358339

2017