Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Advanced GC data suggested that early mutations (APC and TP53) may affect the potential of cancerous progression from D/IEN. 30474112

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Our results also showed that hsa-miR-29c-5p is an important regulator of CDC42 and DNMT3A genes in the intestinal subtype gastric cancer and hsa-miR-135b-5p regulates the APC gene in both intestinal and diffuse subtypes of GC. 30376837

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 PosttranslationalModification BEFREE The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer. 28543390

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE The frequency of genomic alterations seen in SBA demonstrated distinct differences in comparison with either colorectal cancer (APC: 26.8% [85 of 317] vs 75.9% [4823 of 6353], P < .001; and CDKN2A: 14.5% [46 of 317] vs 2.6% [165 of 6353], P < .001) or gastric carcinoma (KRAS: 53.6% [170 of 317] vs 14.2% [126 of 889], P < .001; APC: 26.8% [85 of 317] vs 7.8% [69 of 889], P < .001; and SMAD4: 17.4% [55 of 317] vs 5.2% [46 of 889], P < .001). 28617917

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently detected in the intestinal phenotype of GC, whereas CDH1 gene mutation, microsatellite instability and DNA hypermethylation of MLH1 are common events in the gastric phenotype of GC. 26033320

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 PosttranslationalModification BEFREE Serum RASSF1A and APC promoter hypermethylation is a frequent epigenetic event in patients with early operable gastric cancer. 26073472

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 PosttranslationalModification BEFREE The aim of this study is to examine the expression of β-catenin, APC and E-cadherin in tumour tissues of 80 Tunisian patients with gastric carcinoma and to determine the methylation status of the APC promoter in tumour tissues. 24197976

2014

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Losses of a CNV at 5q22, especially in the DNA region surrounding APC-exon 9, may be associated with a higher risk of gastric cancer. 25210923

2014

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE The frequencies in GC serum were 30.67% for APC, 34.67% for WIF-1, 37.33% for RUNX-3, 29.33% for DLC-1, 33.33% for SFRP-1, 32% for DKK, and 26.67% for E-cad. 23049225

2012

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE We investigated cell cycle regulators (p53, p21, Rb), APC, beta-catenin and NF-kappaB using immunohistochemistry and EBV using in situ hybridisation for EBV encoded small RNAs in 117 cases of gastric carcinoma. 20025482

2010

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Five different classes of methylation behaviors were found: (1) genes methylated in GC only (GSTP1 and RASSF1A); (2) genes showing low methylation frequency (<12%) in CG, IM, and GA, but significantly higher methylation frequency in GC (COX-2, hMLH1, and p16); (3) a gene with low and similar methylation frequency (8.8-21.3%) in four-step lesions (MGMT); (4) genes with high and similar methylation frequency (53-85%) in four-step lesions (APC and E-cadherin); and (5) genes showing an increasing tendency with or without fluctuation of the methylation frequency along the progression (DAP-kinase, p14, THBS1, and TIMP3). 12746473

2003

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Five different classes of methylation behaviors were found: (a). genes methylated in GC only (GSTP1 and RASSF1A), (b). genes showing low methylation frequency (<12%) in CG, IM, and gastric adenoma (GA) but significantly higher methylation frequency in GC (COX-2, hMLH1, p16), (c). a gene with low and similar methylation frequency (8.8-21.3%) in four-step lesions (MGMT), (d). genes with high and similar methylation frequency (53-85%) in four-step lesions (APC and E-cadherin), and (e). genes showing an increasing tendency with or without fluctuation of the methylation frequency along the progression (DAP-kinase, p14, THBS1, and TIMP-3). 12695555

2003

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE APC gene expression in gastric carcinoma: an immunohistochemical study. 12373147

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE THBS1, APC, p16, 14-3-3 sigma, MINT1, and MINT25 were methylated at a frequency >90% in EBV-positive GCs. 11891177

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE APC mutation is involved in carcinogenesis of intestinal type of gastric cancer and is independent of MSI phenotype but related to the LOH pathway in gastric cancer. 12378616

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability. 10605402

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Gastric cancer showed frequent genetic alterations of the APC gene, and the risk for gastric cancer in familial adenomatosus polyposis patients is 10 times higher than that in the general population. 10485468

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE These data suggest that allelic deletion of the p53 gene in intestinal-type gastric carcinoma predicts the invasive potential of mucosal cancer, and that inactivation of the APC gene plays a role in the genetic tumorigenesis of both intestinal and diffuse types of gastric cancer. 9990480

1998

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Thus, LOH at APC and/or MCC is considered to be one of the most prevalent genetic alterations in human gastric carcinoma and occurs at an early stage of the carcinogenesis. 8226275

1993

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Our results suggest that there are distinct differences in the molecular pathogenesis of gastric and pancreatic cancer and that abnormalities of APC and MCC may be involved particularly in the diffuse type of gastric cancer. 8406987

1993

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Since some gastric cancers are considered to originate from the intestinal metaplasia, it is likely that the adenomatous polyposis coli (APC) gene, the mutation of which causes adenomatous polyps in the colon, is associated with carcinogenesis of gastric cancer. 1317264

1992