Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Collectively, this meta-analysis demonstrated that <i>CTLA-4</i> rs5742909 and <i>PLCE1</i> rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians. 31767616

2019

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians. 30784231

2019

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10<sup>-8</sup>), rs10052657 in PDE4D at 5q11.2 (per C allele: OR = 1.12, 95% CI: 1.01-1.25, P = 3.28 × 10<sup>-2</sup>) and rs671 in ALDH2 at 12q24.12 (per A-allele: OR = 0.83, 95% CI: 0.75-0.91, P = 1.14 × 10<sup>-4</sup>) were significantly associated with GC risk. 30202044

2018

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 Biomarker BEFREE This preliminary study suggests that a GWAS-identified genetic variant in PLCE1 may serve as a potential biomarker for GC survival. 29983348

2018

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley. 25434319

2015

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively. 25658482

2015

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. 24254309

2014

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223. 25503145

2014

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Based on 13 676 cases and 23 569 controls, a significant association between PLCE1 rs2274223 and GC risk was detected under various genotypic models. 24985593

2014

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 Biomarker BEFREE These results suggest that PLCε1 might be an alternative molecular target for gastric cancer gene therapy. 24796667

2014

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Odds ratios (OR) with 95% confidence intervals (CI) were employed to assess the association of the PLCE1 rs2274223 polymorphism with a susceptibility to ESCC or gastric cancer. 23826241

2013

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 AlteredExpression BEFREE Firstly, the mRNA and protein expression of PLCε1 were analyzed by reverse transcription-PCR and Western blotting in normal gastric mucous epithelial cell line GES-1 and gastric cancer cell lines AGS, SGC7901, and MGC803. 23077637

2012

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population. 21837401

2011

Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.200 GeneticVariation BEFREE A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). 20729852

2010