Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Our results showed that miR-632 is highly expressed in GC tissue and serum and negatively associated with TFF1 in GC. miR-632 improves tube formation and endothelial cell recruitment by negatively regulating TFF1 in GC cells. 30612555

2019

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE Functionally, miR-196b-5p reconstitution promoted human gastric cancer cell proliferation and invasion <i>in vitro</i> In summary, the current data demonstrate overexpression of miR-196b-5p in gastric cancer and suggest that TFF1 plays an important role in suppressing the expression of miR-196b-5p by mediating DNA methylation of the HOXA10 promoter. 29453320

2018

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE We found that rs3761376 AA in the promoter region of TFF1, could reduce the expression of TFF1 by affecting the binding affinity of estrogen receptor 1 (ESR1, ERα), and thereby increased the risk of GC (1.29, 1.08-1.53). 29210057

2018

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE We also show that TFF1 suppresses NF-κB and inhibits TIMP1-mediated proliferative potential in gastric cancer. 30035371

2018

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Our study demonstrates significant similarities in deregulated transcription networks in human gastric cancer and gastric tumorigenesis in the Tff1-KO mouse model. 28281307

2017

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Collectively, our data demonstrated that the interaction between GKN2 and TFF1 can have synergistic antiproliferative and pro-apoptotic effects on gastric cancer. 28150071

2017

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer. 27598141

2016

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE Additionally, endogenous and exogenous TFF1 were suppressed by miR218-5p in gastric cancer cells and influenced the progression of GC in an Erk1/2-dependent manner. 25652124

2015

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals. 26240479

2015

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE TFF1 activates p53 through down-regulation of miR-504 in gastric cancer. 25015107

2014

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma. 24190027

2014

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE For better understanding of miRNA's contribution to gastric carcinoma (one of the leading causes of cancer-related mortality worldwide), we screened for deregulated miRNAs in blood collected from human cancer patients and compared the expression patterns with a gastric carcinoma mouse model (Tff1 knock-out). 23124995

2013

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE All normal gastric tissues expressed TFF1, but 53.8% of GCs showed reduced TFF1 expression. 23329884

2013

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner. 21870107

2012

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE This study aimed to determine the expression and biological functions of TFF1 and the relationships between TFF1 and GKN1 in gastric cancer. 22842654

2012

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE The present study aimed to determine the role of TFF1 in repairing gastric mucosa and in the pathogenesis of GC. 22642590

2012

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE According to induction of the TFF1 gene by estrogen, it is possible that the substitution of C to T results in a decreased estrogen receptor binding affinity to the estrogen response element and in turn it decreases the expression of the TFF1 gene that may be involved in development of gastric cancer over a lifetime. 22093877

2012

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 PosttranslationalModification BEFREE Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin. 21111741

2011

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE This indicates that TFF1 expression in the absence of TFIZ1 expression has potentially deleterious consequences in gastric cancer. 18722547

2009

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Recently, TFF1 mutations have been found in human gastric cancer. 16697734

2006

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE The reduced expression of TFF1 and TFF2 in precancerous conditions and gastric cancer may be associated with the proliferation and malignant transformation of gastric mucosa. 16718800

2006

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE The expression of TFF1 in normal and abnormal gastric tissues (gastric carcinoma, atypical hyperplasia and intestinalized gastric mucosa) was also assayed by immunohistochemical method. 17143957

2006

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Overexpression of CEBPbeta correlates with decreased TFF1 in gastric cancer. 16247479

2006

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE TFF1 and TFF2 mRNAs are frequently down-regulated in intestinal-type gastric cancer. 12792801

2003

Entrez Id: 7031
Gene Symbol: TFF1
TFF1
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE TFF1 was down-regulated in 7 cases out of 12 cases (58.3%) of primary gastric cancer. 12168114

2002