Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE To investigate the relations between anaplastic lymphoma kinase (<i>ALK</i>) and v-myc myelocytomatosis viral related oncogene neuroblastoma derived homolog (<i>MYCN</i>) protein expression and their prognostic roles in neuroblastoma tumours. 31542727

2020

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Since most cases are in children under the age of 2, understanding the role and regulation of ALK during neural crest development is an important goal in addressing neuroblastoma tumorigenesis. 30803032

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE These data confirm that PIM1 overexpression decreases sensitivity to ALK inhibitors in NB, and suggests that combined front-line inhibition of ALK and PIM1 is a viable strategy for the treatment of ALK-positive NB independent of MYCN status. 31780656

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE ALK-amplified NBs were correlated with synchronous MYCN amplification and chromosome 1p deletion. 28326957

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Studies have shown that native ALK protein is expressed on the surface of most neuroblastoma cells, providing an opportunity for development of immune-targeting strategies. 30867324

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Altogether, this study provides novel insights into ALK mutation dynamics in a neuroblastoma model harbouring two ALK mutations. 31452835

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The agent targets ALK, which is found on neuroblastoma cells but not healthy cells, delivering a drug that causes DNA cross-links. 31043380

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Multiple therapeutic approaches are being used to target MYCN, ALK, and TrkB, as well as GD2, a surface antigen present on the surface of neuroblastoma tumor cells. 31092383

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Three hotspot residues (F1174, F1245, and R1275) account for 85% of mutant ALK seen in neuroblastoma. 30778092

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The results suggest that alectinib is an effective inhibitor of ALK kinase activity in ALK addicted neuroblastoma and should be considered as a potential future therapeutic option for ALK-positive neuroblastoma patients alone or in combination with other treatments. 31334113

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Mutations in the Anaplastic lymphoma tyrosine kinase (ALK) gene are common in NB. 30605844

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Resistance to ALK Inhibitors in Neuroblastoma Is Regulated by BORIS. 31420353

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Through a case study of mutations in kinase domains of three proteins, namely, the anaplastic lymphoma kinase (ALK) in pediatric neuroblastoma patients, serine/threonine-protein kinase B-Raf (BRAF) in melanoma patients, and erythroblastic oncogene B 2 (ErbB2 or HER2) in breast cancer patients, we compare the two approaches above. 30982079

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Mechanisms of acquired resistance to ALK inhibition therapy in neuroblastoma have not yet been elucidated. 31614113

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Although expression of ALK F1174L resulted in enhanced proliferation of sympathetic ganglion progenitors and increased the size of the sympathetic ganglia, it was insufficient to cause neuroblastoma. 31218818

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE ALK overexpression and activation, in the absence of genetic mutation has also been described in NB. 31340081

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Combined treatment with alectinib and vorinostat might be a novel therapeutic option for NB harboring the ALK R1275Q mutation. 31262882

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The Anaplastic Lymphoma Kinase (<i>ALK</i>) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis when mutated. 31058082

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE We review the basic aspects of MYCN, Trk, and ALK in both neural development and in neuroblastoma. 30848386

2019

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In this study, we established both phosphoproteomic and gene expression profiles of ALK activity in neuroblastoma cells exposed to first- and third-generation ALK TKIs, to identify the underlying molecular mechanisms and identify relevant biomarkers, signaling networks, and new therapeutic targets. 30459281

2018

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Bioinformatic analyses revealed that the mRNA expression level of HDAC8 was significantly correlated with that of ALK in two independent patient cohorts, the Academic Medical Center cohort (n = 88) and the German Neuroblastoma Trial cohort (n = 649), and co-expression of both target genes identified patients with very poor outcome. 29515255

2018

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion with other oncogenes (NPM, EML4, TIM, etc) or gene amplification, mutation or protein overexpression. 29455642

2018

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Recently, truncated ALK protein was also reported in neuroblastoma. 28665006

2018

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Alterations in anaplastic lymphoma kinase (<i>ALK</i>) gene are involved in neuroblastoma, lung cancer, and other malignancies, but its role in SCCP has not been documented. 29559559

2018

Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE We demonstrate that ETV5 is regulated both at the protein and mRNA levels upon ALK activation or inhibition in neuroblastoma cell lines and that this regulation precedes RET modulation. 29321660

2018