Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Since BDNF is reported to stimulate VEGF expression and/or release in neuroblastoma cells, the present study tested the hypothesis that the actions of BDNF are mediated by VEGF. 30712809

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE The compound dose-dependently inhibited brain-derived neurotrophic factor (BDNF)-mediated TrkB activation and suppressed migration and invasion of SH-SY5Y-TrkB neuroblastoma cells expressing high level of TrkB. 31271959

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE BDNF-VI mRNA expression in SH-SY5Y cells was significantly improved by pretreatment with quercetine, astaxanthin, curcumin, fisetin, and resveratrol. 29378496

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Overall, our finding supports that DLX6-AS1 promotes NB progression by regulating miR-107/BDNF pathway, acting as a novel therapeutic target for NB. 31787850

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE SIGNIFICANCE STATEMENT: The tropomyosin-related kinase receptor B (TrkB) mediates the stimulatory effects of brain-derived neurotrophic factor (BDNF) on neuronal growth, differentiation, and survival and is highly expressed in aggressive neuroblastoma and other tumors. 31308194

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE We then used neuronal human derived neuroblastoma cell line (SH-SY5Y) cells with inducible MeCP2 expression from a second copy of the gene as a gain-of-function model and found that MeCP2 overexpression positively affected p-CREB and BDNF expression initially. 30806012

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE GZD2202 suppresses the brain-derived neurotrophic factor (BDNF) -mediated TrkB signalling pathway, proliferation, migration and invasion in SH-SY5Y-TrkB neuroblastoma cells, and causes about 36.1% growth inhibition in a SH-SY5Y-TrkB neuroblastoma xenograft model. 30301369

2019

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In this study, we investigated the roles of P53 and BCL2 family members in the protection of BDNF/TrkB from etoposide-induced NB cell death. 29959561

2018

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 PosttranslationalModification BEFREE The compounds were subjected to assays using the luciferase-reporter gene under the control of the BDNF promoter or cAMP response element in mouse neuroblastoma Neuro-2a cells. 29063362

2018

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Here, we demonstrated that synaptic activity- and brain-derived neurotrophic factor (BDNF)-dependent local activation of UPR signaling could be associated with dendritic functions through retrograde signal propagation by using murine neuroblastoma cell line, Neuro-2A and primary cultured hippocampal neurons derived from postnatal day 0 litter C57BL/6 mice. 28921568

2018

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Conversely, overexpression of synapsins in neuroblastoma cells results in corresponding reciprocal changes in raft lipid composition, increased localization of Fyn to rafts and promotion of BDNF-stimulated neurite formation. 28245069

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE In addition, overexpression of either PGC-1α or FNDC5 reversed the suppressive effects of the Aβ<sub>1-42</sub> oligomers on the expression of BDNF in neuroblastoma 2a (n2a) cells. 28377712

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE In the present study, we investigated the effects of propolis on oxidative stress, expression of brain-derived neurotrophic factor (BDNF), and activity-regulated cytoskeleton-associated protein (Arc), the critical factors of synapse efficacy, using human neuroblastoma SH-SY5Y cells. 28265338

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Additionally, NPY and Y5R were upregulated in a BDNF-independent manner in NB cells under pro-apoptotic conditions, such as serum deprivation and chemotherapy, as well as in cell lines and tissues derived from posttreatment NB tumors. 25132261

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE TrkB activation by brain-derived neurotrophic factor (BDNF) contributes to chemo-resistance in neuroblastoma (NB). 25700942

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE The neurotrophin receptor TrkB and its ligand brain-derived neurotrophic factor (BDNF) are expressed at high levels in high-risk NBs and are involved in defining the poor prognosis of the patients. 24403123

2014

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of Aβ's pathogenic fragment 25-35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons. 25026432

2014

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE This interaction is functional; overexpression of FTO delays the dephosphorylation of cAMP response element-binding protein (CREB) in human neuroblastoma (SK-N-SH) cells, which in turn leads to a dramatic increase in the expression of the CREB targets neuropeptide receptor 1 (NPY1R) and brain-derived neurotrophic factor (BDNF), which already are known to regulate food intake and energy homeostasis. 24488767

2014

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma. 24253178

2014

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE BDNF mRNA was measured in neuroblastoma SH-SY5Y cells after incubation with sera from B. longum- or placebo-treated mice. 21988661

2011

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Although it is not yet known if this interaction contributes to neuroblastoma disease pathogenesis, it is intriguing that the interaction occurs at the promoter regions of several genes important for the development of neuroblastoma, including ALK, AURKA and BDNF. 21731748

2011

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Expression of brain-derived neurotrophic factor (BDNF) was stimulated in human neuroblastoma SH-SY5Y cells by a nonprotein extract of inflamed rabbit skin inoculated with vaccinia virus (Neurotropin), an analgesic widely used in Japan for treatment of disorders associated with chronic pain, with the optimal dosage at 10mNU/mL. 20600926

2010

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Recently, BDNF was identified as a potential proangiogenic factor for the promotion of endothelial cell survival, induction of neoangiogenesis in ischemic tissues, and increase of VEGF expression in neuroblastoma. 20331634

2010

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Although expression of the high-affinity neurotrophin receptors, TrkA and TrkB, is of major importance in neuroblastoma, the significance of the expression of the low-affinity neurotrophin receptor, p75, is unclear. 19142969

2009

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Alternative splicing of the neurotrophin receptor tyrosine kinase TrkA may have a pivotal function in regulating NB behaviour, with reports suggesting that tumour-suppressing signals from TrkA may be converted to oncogenic signals by stress-regulated alternative TrkAIII splicing. 19734938

2009