Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In this short review, we will discuss the most relevant genomic rearrangements that define high-risk NB and the role that destabilization of p53 and p73 can have in NB aggressiveness. 26633716

2015

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The p53 family proteins, p73 and p63, can also induce apoptosis, and early studies suggest that p73 may be important in neuroblastoma pathogenesis and response to treatment. 20222799

2010

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Here, we report that cyclooxygenase (COX) inhibitors induce apoptosis independent of p53, and differentially modulate endogenous p73 isoforms in neuroblastoma and other tumors. 19363520

2009

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE We have previously shown that p73 isoforms are deregulated in NB tumours and that TAp73 co-operates synergistically with p53 for apoptosis of NB cells, whereas DeltaNp73 activates the expression of neuronal differentiation genes such as BTG2. 18583365

2008

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Valproic acid diminished N-myc and enhanced p73 protein level, coupled with downregulation of deltaNp73 in UKF-NB-3(VCR) and UKF-NB-3(CDDP). 17505515

2007

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Differential regulation of p73 variants in response to cisplatin treatment in SH-SY5Y neuroblastoma cells. 16773194

2006

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE The p53 gene and its homologue p73 are rarely mutated in neuroblastoma. 15741235

2005

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The present study investigates whether there is a functional link between p73 isoforms and p53 in neuroblastoma. 14676279

2004

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE However, altered expression of the p73 gene has been reported in neuroblastoma, lung cancer, prostate cancer and renal cell carcinoma. 15385938

2004

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. 15650242

2004

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE The N-myc gene was transfected into two neuroblastoma cell lines that lacked N-myc amplification to determine its effect on p73 RNA levels. p73 was detectable at low level by RT-PCR in untransfected SK-N-AS cells and became undetectable following N-myc transfection, whereas in SH-EP1 cells, p73 levels were substantially reduced following transfection but remained detectable. 12192602

2003

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE This review summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma. 12880969

2003

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Although p73 maps at 1p36.3 and is frequently deleted in neuroblastoma (NB), it does not act as a classic oncosuppressor gene. 11859407

2002

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE These results are supportive of a role for p73 in the biology of neuroblastoma, particularly in some advanced tumors. 11205839

2001

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Although p73 is infrequently mutated in human cancers, we have previously found two types of p73 mutation with amino acid substitution (P405R and P425L) in primary neuroblastoma and lung cancer. 11429704

2001

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 PosttranslationalModification BEFREE We concluded that it is unlikely that p73 is imprinted in neuroblastoma and that the methylation-dependent silencing of this gene, thus far, is a characteristic of hematologic malignancies.Oncogene (2000) 19, 4553 - 4556. 11002429

2000

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified. 10601564

2000

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE The p63 and p73 genes are rarely mutated in human cancer, although p73 loss is observed in neuroblastoma and a subtype of T-cell lymphoma. p53, p63 and p73 appear to have overlapping and distinct functions: p53 regulates the stress response to suppress tumors; p63 is essential for ectoderm development; and p73 might regulate both the stress response and development. 10769197

2000

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE We conclude that the p73 gene is less involved in the development but involved in the progression of neuroblastoma. 10719054

2000

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE Alteration of the p53 tumor suppressor gene is a common, if not general, observation in human malignant tumors. p73 Is a novel member of the p53 family at chromosome 1p36.3, at which locus frequent defects are seen in many tumors including neuroblastoma. 10972855

2000

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE A novel p73 gene, which is related to p53, has recently been identified and mapped to chromosome 1p36.3, which is a locus of multiple tumour-suppressor genes for many cancers, including hepatocellular carcinoma (HCC) and neuroblastoma. 10408709

1999

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In conclusion, we could find no evidence for p73 being the neuroblastoma tumor suppressor gene in 1p36. 10341287

1999

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE The p73 gene is monoallelically expressed in normal tissue, maps to chromosome 1p36 and is deleted in human neuroblastoma cell lines. 10213163

1999

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Sequence analysis of the p73 coding region in the mRNAs expressed by these cell lines and tumors did not reveal inactivating mutations, suggesting that p73 is not homozygously inactivated in neuroblastoma. 10935473

1999

Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 GeneticVariation BEFREE However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner. 10023682

1999