Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE This refinement of the association between FGFR2 variants and ER-status to HER2-negative disease provides novel insight to potential biological and clinical influence of genetic polymorphisms on breast tumors. 27764800

2016

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE Moreover, the increased risk conferred by the minor FGFR2 allele associates most strongly in oestrogen receptor alpha positive (ERα) breast tumours, suggesting a potential interaction between ERα and FGFR signalling. 24265722

2013

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression BEFREE FGFR2 and FGF10, the main ligand of FGFR2, are both overexpressed in 5-10% of breast tumors. 23527311

2013

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE In a population-based case-control study of 1,170 breast cancer cases and 2,115 controls, we examined genetic associations of four intronic FGFR2 single-nucleotide polymorphisms (SNPs) and breast tumor characteristics and assessed the potential interactions with smoking, alcohol consumption, adiposity and known breast cancer risk factors. 20853316

2011

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression BEFREE In 25 breast tumors, no associations between breast tumor characteristics and fibroblast FGFR2 mRNA levels were found. 21767389

2011

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker BEFREE Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. 18767044

2008

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression BEFREE In conclusion, three consecutive microarray (CGH, cDNA and tissue) experiments revealed high-level amplification and overexpression of the FGFR2 in a breast cancer cell line, but only a low frequency of involvement in primary breast tumors. 11564899

2001

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker BEFREE For two of these regions, 8p12 and 10q26, we previously reported the amplification of genes encoding FGF receptors, FGFRI/FLG and FGFR2/BEK, in about 12% of breast tumors. 7692948

1993

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker BEFREE BEK and FLG were found amplified in 11.5 and 12.7% of breast tumors respectively. 1851551

1991