Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours. 30819233

2019

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Cyclin D1-dependent induction of luminal inflammatory breast tumors by activated notch3. 23928992

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Fluorescent in-situ hybridization was performed on a tissue microarray of 495 breast tumors (74% of patients) to measure CCND1 and RSF1 copy number. 24367492

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE High cyclin D1 expression statistically significantly correlated with lower tumor grade, estrogen and progesterone receptor positivity and lower proliferation activity in breast tumors and increased breast cancer-specific survival and overall survival. 23336272

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE A set containing 281 CCND1-non-amplified breast tumours was used for comparisons. 22002566

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE The results obtained suggest that the increment of the levels of cyclin D1 in intra-ductal breast tumors in older woman that we have examined is significantly associated with a lower proliferation rate. 22231956

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE CCND1 was amplified in 4% of BRCA1-associated, 13% of BRCA2-associated and 21% of non-BRCA1/BRCA2 breast tumors (P = 0.054). 21327470

2011

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation BEFREE Subgroup analysis showed associations between carriers of the E2F2_-5368_G allele (OR: 0.60, 95% CI: 0.42-0.85), carriers of the CCND1_870_G allele (OR: 0.66, 95% CI: 0.45-0.96) and carriers of the CCND3_-677_T allele (OR: 1.72, 95% CI: 1.20-2.49) and HER2 expression in breast tumors. 19142864

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines. 18695042

2008

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE These results strongly suggest that daintain/AIF-1 can promote the growth of breast tumors via activating NF-kappaB signaling, which consequently up-regulates the expression of cyclin D1, implying that daintain/AIF-1 may be a novel target molecule for the prognosis and therapy of breast cancer. 18341653

2008

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation BEFREE From this study, we conclude that development of (pre-malignant) breast tumors in either wild type or MMTV-cyclin D1 mice was not augmented due to mammary gland targeted overexpression of human cortactin. 16536875

2006

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. 16980615

2006

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation BEFREE In previous studies, the complete loss of cyclin D1 through homozygous genetic deletion conveyed breast tumor resistance. 15314168

2004

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Analysis of different deleted regions in chromosome 11 and their interrelations in early- and late-onset breast tumors: association with cyclin D1 amplification and survival. 15322430

2004

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE BRCA1-regulated genes associated with breast tumorigenesis included the estrogen-responsive genes MYC and cyclin D1, which are overexpressed in many breast tumors; STAT1 and JAK1, key components of the cytokine signal transduction pathway; the extracellular matrix protein laminin 3A; ID4, an inhibitor of DNA-binding transcriptional activators, which in turn negatively regulates BRCA1 expression; and the prohormone stanniocalcin, expression of which is lost in breast tumor cells. 12032322

2002

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE We have previously shown that Pin1 is overexpressed in breast tumors and positively regulates cyclin D1 by transcriptional activation and posttranslational stabilization. 12101225

2002

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE CCND1 overexpression was observed in 44 (32.8%) of 134 breast tumour RNAs, ranging from 3.3 to 43.7 times the level in normal breast tissues, and correlated significantly with positive oestrogen receptor status (P=0.0003). 11870541

2002

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation BEFREE Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers. 11477142

2001

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE Cyclin D1 is overexpressed in 20-30% of human breast tumors and is induced both by oncogenes including those for Ras, Neu, and Src, and by the beta-catenin/lymphoid enhancer factor (LEF)/T cell factor (TCF) pathway. 10915780

2000

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE Analysis of p53 mutation and cyclin D1 expression in breast tumors. 10393358

1999

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE In this study, the effect of cyclin D1 on radiosensitivity was investigated in a breast tumor cell line, MCF7, containing a cyclin D1 gene construct under the control of a tetracycline-sensitive regulator. 10070974

1999

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Three of these proteins, cyclin D1, pRb and p16, were analysed by immunohistochemistry on archival paraffin sections to determine whether expression patterns were different in preinvasive ductal carcinoma in situ (DCIS) and invasive breast tumours relative to normal. 9652762

1998

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE CCND1 and FGFR1 coamplification results in the colocalization of 11q13 and 8p12 sequences in breast tumor nuclei. 9669664

1998

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE AIB1 and CCND1 amplifications may, thus, represent two different subsets of ER-positive breast tumors. 9865902

1998

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE Overexpression of cyclin D1 in MCF7 breast tumor cells resulted in a continued proliferation under low-serum conditions, whereas nonoverexpressing cells ceased to grow. 8649362

1996