Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE LncRNA-XIST functioned as a competing endogenous RNA of miR-126 and then regulated IRS1/PI3K/Akt pathway in glioblastoma cells. 31680298

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. 31841506

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells. 30669284

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 GeneticVariation BEFREE The objective of this study was to examine whether PIK3CA mutations are associated with a specific clinical phenotype in glioblastoma. 31036078

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Using single-cell tracking and wound healing migration tests, colony-forming assay, Western blotting, flow cytometry and electrorotation we examined the effects of MK-2206 and PI-103 and/or irradiation on the migration, radiation sensitivity, expression of several marker proteins, DNA damage, cell cycle progression and the plasma membrane properties in two glioblastoma (DK-MG and SNB19) cell lines, previously shown to differ markedly in their migratory behavior and response to PI3K/mTOR inhibition. 30943918

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Nevertheless, the administration of the dual PI3K/mTOR inhibitor BEZ235 potentiated the effect of TMZ plus MET on cell viability, inducing a pro-apoptotic phenotype during hypoxic condition also in T98 cells, suggesting the block of the PI3K/AKT/mTOR pathway as a complementary target to further overcome GBM resistance during hypoxia. 31214505

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Specifically, targeting cellular pathways frequently altered in glioblastoma, such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), the p53 and the retinoblastoma (RB) pathways, or epidermal growth factor receptor (EGFR) gene amplification or mutation, have failed to improve outcome, likely because of redundant compensatory mechanisms, insufficient target coverage related in part to the blood brain barrier, or poor tolerability and safety. 31541850

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Additionally, we found no effect of the VRAC inhibition using siRNA treatment or DCPIB on PI3K/Akt signaling in glioblastoma cells. 31151189

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 AlteredExpression BEFREE Therefore, while under normoxic conditions, EGF stimulates the activation of both the PI3K and the MAPK pathways and the induction of VEGF, in glioblastoma cells, hypoxic conditions lead to the suppression of the PI3K/RhoA/C pathway and an exclusive switch to the MAPK pathway. 31698752

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 AlteredExpression BEFREE Notch activity in GBM was also shown to be associated with hypoxia and certain cancer-related molecular pathways such as PI3K/AKT/mTOR and ERK/MAPK. 31376551

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE The PI3K/AKT/mTOR pathway activation plays a central role in glioblastoma multiforme (GBM) development and progression, and in resistance to anti-cancer therapies. 31707687

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Tivantinib (1 μmol/L) in combination with PI3K inhibitor LY294002 (0.5 μmol/L) and mTOR inhibitor rapamycin (0.1 nmol/L) largely inhibited the proliferation of glioblastoma cells. 31575848

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 GeneticVariation BEFREE Genomic analyses reveal that signature genetic lesions in GBM and LGG include copy gain and amplification of chromosome 7, amplification, mutation, and overexpression of receptor tyrosine kinases (RTK) such as EGFR, and activating mutations in components of the PI3K pathway. 30530503

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE SIGNIFICANCE: These findings provide novel insights into the mechanisms of PI3K inhibitor resistance in glioblastoma. 31416846

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Serum‑derived hepatitis C virus can infect human glioblastoma cell line SF268 and activate the PI3K‑Akt pathway. 30896873

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 AlteredExpression BEFREE Here we show that overexpression of NEU3 in glioblastoma U87MG cells activates PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation. 30466783

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 AlteredExpression BEFREE GDC-0084 is a brain penetrant, dual PI3K/mTOR inhibitor that has shown promising activity in a preclinical model of glioblastoma. 30796030

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE The Oncogene Addiction Switch from NOTCH to PI3K Requires Simultaneous Targeting of NOTCH and PI3K Pathway Inhibition in Glioblastoma. 30669546

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE These results demonstrated that miR-605 acts as a tumor suppressor in the development of GBM by directly targeting SOX9 and inhibiting the activation of the PI3K/Akt pathway, suggesting its potential role as a therapeutic target for GBM. 31360068

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE At last, rescue assays validated that PI3K/Akt/mTOR signaling pathway involved in the glioblastoma progression mediated by SNHG20. 30943748

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Mutations in TERT, CDKN2A/CDKN2B, EGFR, and PI3K pathway were commonly observed in both primary and recurrent GBM revealing their prognostic and therapeutic potential. 30535594

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 AlteredExpression BEFREE In conclusion, DPT effectively inhibited the expression of PI3K and downregulated PI3K/Akt‑mediated signaling pathways to prevent glioblastoma progression. 30816477

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Molecular genetic aberrations in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway are common in human cancers including glioblastoma, yet, novel therapeutic approaches targeting this pathway in glioblastoma have not been successful. 31618458

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE PIP4K2A as a negative regulator of PI3K in PTEN<i>-</i>deficient glioblastoma. 30898893

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE Chen and colleagues leverage a <i>Drosophila</i> GBM model to identify a conserved signaling axis downstream of the EGFR and PI3K that involves the death-associated protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase STK17A. 30877099

2019