Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756

2019

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET The variants at ANK3 and CACNA1C previously known to be associated with BP were not in linkage disequilibrium with either of the two variants that we identified and these are therefore independent of the previous haplotypes implicated by genome-wide association. 24716743

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. 25304227

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET In treatment of BD with calcium channel blocking drugs, we would predict better response in patients without the risk allele, because they have increased CACNA1C expression. 23979604

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. 25290268

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker CTD_human Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972

2011

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker CTD_human In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)). 21926974

2011

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker CTD_human Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365

2008