Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker PSYGENET We report the effect of CYP2C19 and CYP2D6 genotypes on steady state morning concentrations of escitalopram and N-desmethylescitalopram and the ratio of this metabolite to the parent drug in 196 adult patients with depression in GENDEP, a clinical pharmacogenomic trial. 21926427

2012

Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker PSYGENET The Sequenced Treatment Alternatives to Relieve Depression sample was used to examine the relationship between variations in the CYP2C19 and CYP2D6 genes and remission of depressive symptoms and tolerance to treatment with citalopram. 21192344

2011

Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker PSYGENET We evaluated whether cytochrome P450 (CYP) poor metabolizer polymorphisms of CYP2D6 and CYP2C19 are relevant for the outcome (measured by length of hospitalization) during treatment with psychotropic medications in patients with depression or schizophrenia. 16812949

2006

Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker PSYGENET Genetic tests suitable for the routine laboratory are now available for some important metabolizing enzymes (e.g., CYP2D6, CYP2C19) identifying those individuals who are slow or fast metabolizers of certain drugs, many of which are widely used in the treatment of depression (e.g., tricyclic antidepressants). 11412815

2001