Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET Our study provides strong evidence that Gent inhibits reserpine-induced pain/depression dyad by downregulating GluN2B receptors in the amygdala. 24584520

2014
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET Indeed, we observed a significant reduction of NMDA-induced field excitatory postsynaptic potential depression in the hippocampus of Tau mice together with a reduced phosphorylation of NR2B at the Y1472, known to be critical for NMDAR function. 23082852

2013
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET In addition, we demonstrate that while stress increased NMDA NR2B-mediated synaptic transmission, known to be implicated in depression, Reelin overexpression significantly reduced it. 21814183

2011
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. 20357110

2010
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. 19838302

2009