Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.430 Biomarker PSYGENET These combined data support a physical interaction between PS-1 and MAO-A that could influence MAO-A activity and contribute to the monoaminergic disruptions common to disorders as seemingly diverse as depression and AD. 22045496

2012

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.430 Biomarker PSYGENET Finally, we demonstrate that the two PS-1 variants reported to be associated with an increased incidence of clinical depression [e.g., A431E and L235V] both induce MAO-A activity in HT-22 cells. 21373759

2012

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.430 Biomarker PSYGENET For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. 20052609

2010

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.430 Biomarker PSYGENET Depressive symptoms can occur early in the course of PS1 related Alzheimer's disease, at least in women. 14966176

2004

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.430 Biomarker PSYGENET Although basal synaptic transmission, long-term potentiation, and long-term depression at hippocampal area CA1 synapses are normal, the PS1 cKO mice exhibit subtle but significant deficits in long-term spatial memory. 11567612

2001