Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk. 27318894

2016

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human The addition of a dual inhibitor of 5-a-reductase types 1 and 2 to antiandrogen therapy may further inhibit tumor growth, thus reducing the concentration of intracellular dihydrotestosterone, which is the primary androgen mediator of PSA gene expression in prostate tumor cell lines. 18500220

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. 18676866

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Multiple newly identified loci associated with prostate cancer susceptibility. 18264097

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Differential regulation of clusterin and its isoforms by androgens in prostate cells. 17148459

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells. 17003774

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Pretreatment serum level of HER2/nue as a prognostic factor in metastatic prostate cancer patients about to undergo endocrine therapy. 16984552

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Randomized Phase II study comparing paclitaxel and carboplatin versus mitoxantrone in patients with hormone-refractory prostate cancer. 16442593

2006

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors. 16424004

2006

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Endocrine approaches in the therapy of prostate carcinoma. 15790600

2005

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer. 12644816

2003