Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT The HOXB13 p.G84E mutation has been firmly established as a prostate cancer susceptibility allele. 27424772

2016

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. 26457646

2016

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT For example, a recent study suggested that one cannot adequately impute the HOXB13 G84E mutation associated with prostate cancer risk (carrier frequency of 0.0034 in European ancestry participants in the 1000 Genomes Project). 25629170

2015

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human Here we find that the prostate cancer risk-associated SNP rs339331 at 6q22 lies within a functional HOXB13-binding site. 24390282

2014

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human Human HOX gene disorders. 24239177

2014

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. 24390282

2014

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human Together, our results suggest that rs339331 affects prostate cancer risk by altering RFX6 expression through a functional interaction with the prostate cancer susceptibility gene HOXB13. 24390282

2014

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe. 23104005

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT The germline mutation G84E of HOXB13 is a rare but recurrent mutation associated with elevated risk of prostate cancer in men of European descent, with an effect size that is greater than observed for previously validated risk variants of genome wide association studies. 22714738

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT A recent study of familial and early onset prostate cancer reported a recurrent rare germline mutation of HOXB13 among men of European descent. 22714738

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT To examine this finding in a large international sample of prostate cancer families, we genotyped this mutation and 14 other SNPs in or flanking HOXB13 in 2,443 prostate cancer families recruited by the International Consortium for Prostate Cancer Genetics (ICPCG). 23064873

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT Our study confirmed the association between the G84E mutation of HOXB13 and risk of prostate cancer among subjects of European descent. 22714738

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT Recently, a rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate cancer risk. 23064873

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT A recently identified germline mutation G84E in HOXB13 was shown to increase the risk of prostate cancer. 23292082

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT This study confirms the overall importance of the HOXB13 G84E mutation in prostate cancer susceptibility. 23292082

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). 23064873

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT These findings demonstrate that the HOXB13 G84E mutation is present in ~5 % of prostate cancer families, predominantly of European descent, and confirm its association with prostate cancer risk. 23064873

2013

Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation UNIPROT Germline mutations in HOXB13 and prostate-cancer risk. 22236224

2012