Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer. 28783165

2017

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Here we show that the most common PCa-associated truncated ERG T1-E4 (ERGΔ39), encoded by fusion between TMPRSS2 exon 1 and ERG exon 4, binds to bromodomain-1 (BD1) of bromodomain containing protein 4 (BRD4), a member of the bromodomain and extraterminal domain (BET) family. 27223260

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Our findings reveal that PCa-associated ERG can interact and co-occupy with BRD4 in the genome, and suggest this druggable interaction is critical for ERG-mediated cell invasion and PCa progression. 27223260

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer. 27783944

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Integrative molecular profiling of routine clinical prostate cancer specimens. 25735316

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human BET bromodomain-mediated interaction between ERG and BRD4 promotes prostate cancer cell invasion. 27223260

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human One potential therapeutic target is ERG, a transcription factor aberrantly up-regulated in PCa due to chromosomal rearrangements between androgen-regulated gene TMPRSS2 and ERG. 27223260

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human We provide further evidence that ERG-mediated invasion of PCa cells was significantly enhanced by an acetylation-mimicking mutation in ERG that augments the ERG-BRD4 interaction. 27223260

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human We find that prostate cancer specimens containing the TMPRSS2-ERG rearrangement are significantly enriched for loss of the tumor suppressor PTEN. 19396168

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Here, we exposed ERG-positive prostate cancer cell lines to HDAC inhibitors Trichostatin A (TSA), MS-275 and suberoylanilide hydroxamic acid (SAHA) with or without androgen deprivation. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Our results support the hypothesis that HDACi, especially in combination with androgen deprivation, is effective against TMPRSS2-ERG-fusion positive prostate cancer in vitro. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Gene fusions between prostate-specific, androgen responsive TMPRSS2 gene and oncogenic ETS factors, such as ERG, occur in up to 50% of all prostate cancers. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Together with our previous in vivo observations of an "epigenetic reprogramming gene signature" in clinical ERG-positive prostate cancers, these studies provide mechanistic insights to ERG-associated tumorigenesis and suggest therapeutic paradigms to be tested in vivo. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human We recently defined a gene signature that was characteristic to prostate cancers with ERG activation. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant ERG expression is controversial. 19396168

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Thus, ERG has a distinct role in prostate cancer progression and cooperates with PTEN haploinsufficiency to promote progression of HGPIN to invasive adenocarcinoma. 19396168

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human We then hypothesized that patients with ERG-positive prostate cancers may benefit from epigenetic therapy such as HDAC inhibition (HDACi), especially in combination with antiandrogens. 18798265

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Integrative molecular concept modeling of prostate cancer progression. 17173048

2007