Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human This study demonstrated the IL6-Stat3-AR axis in prostate cancer is one of the crucial mechanisms of enzalutamide resistance. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Knock down of Stat3 abrogated enzalutamide resistance resulting in reduced recruitment of AR to the PSA promoter in prostate cancer cells expressing IL6. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Knock down of Stat3 abrogated enzalutamide resistance resulting in reduced recruitment of AR to the PSA promoter in prostate cancer cells expressing IL6. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human This study demonstrated the IL6-Stat3-AR axis in prostate cancer is one of the crucial mechanisms of enzalutamide resistance. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human It is known that over expression of IL6 in prostate cancer cells confer enzalutamide resistance and that this may occur through constitutive Stat3 activation. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human It is known that over expression of IL6 in prostate cancer cells confer enzalutamide resistance and that this may occur through constitutive Stat3 activation. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. 25970160

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human These results show that overexpression of IL-6 increases the resistance of prostate cancer cells to bicalutamide via TIF2. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. 19011039

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human These results show that overexpression of IL-6 increases the resistance of prostate cancer cells to bicalutamide via TIF2. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Overexpression of IL-6 not only plays an important role in prostate cancer progression but also contributes to bicalutamide resistance. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. 19011039

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Overexpression of IL-6 not only plays an important role in prostate cancer progression but also contributes to bicalutamide resistance. 19240160

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Using PC-3 and DU145 human prostate cancer cells, we analyzed the role of SAPKs in IL-6 mediated cell growth and found that the p38MAPK and JNK are involved in androgen-independent cancer cell growth. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Using PC-3 and DU145 human prostate cancer cells, we analyzed the role of SAPKs in IL-6 mediated cell growth and found that the p38MAPK and JNK are involved in androgen-independent cancer cell growth. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Since prostate cancer gradually progresses to an androgen-independent state despite the stress caused by various therapeutic agents, we hypothesized the stress-activated protein kinases (SAPKs) involvement in androgen-independent growth or IL-6 secretion of prostate cancer cells. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Therapeutic CTD_human Since prostate cancer gradually progresses to an androgen-independent state despite the stress caused by various therapeutic agents, we hypothesized the stress-activated protein kinases (SAPKs) involvement in androgen-independent growth or IL-6 secretion of prostate cancer cells. 17196171

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6-mediated activation of the androgen receptor. 15672864

2005

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Interleukin-6 (IL-6) is considered to contribute to CaP progression and is produced at high levels in osteoblasts. 15672864

2005

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker CTD_human Anti-IL-6 antibody added to HOBIT or POB CM dose-dependently inhibited the CM-induced cell proliferation and PSA expression in these CaP cell lines. 15672864

2005