×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Estrogen Receptor Alpha (ER) is expressed in about 70% of breast cancer and mediates various cellular signaling events including cell cycle.
27580430
2016
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
25330770
2014
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer .
24185512
2013
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Taken together, these studies suggest that activating mutations in ESR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy.
24185510
2013
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro.
24014025
2013
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Our results show that breast cancer risk-associated SNPs are enriched in the cistromes of FOXA1 and ESR1 and the epigenome of histone H3 lysine 4 monomethylation (H3K4me1) in a cancer- and cell type-specific manner.
23001124
2012
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions.
22038807
2012
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR-1 gene overexpression happens frequently in breast cancer , but only a subset of them are high amplified cases correlated to increased response rates in hormonal therapy (tamoxifen).
20458558
2011
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR1 amplification as detected by MLPA is rare in breast cancer , and seems to be associated with high ERα expression, high age, high grade and high proliferation.
21541733
2011
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization.
21501481
2011
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
The Possible Impact of Obesity on Androgen, Progesterone and Estrogen Receptors (ERα and ERβ) Gene Expression in Breast Cancer Patients.
22174584
2011
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
The novel estrogen receptor -alpha (ER-alpha) variant ER-alpha36 is reported to be functional in the estrogen signaling pathway and is related to tamoxifen resistance in breast cancer .
20104649
2010
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR1 amplification as detected by MLPA is rare in breast cancer , and seems to be associated with high ERα expression, high age, high grade and high proliferation.
20966540
2010
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
A subsequent tissue microarray analysis of more than 2,000 clinical breast cancer samples showed ESR1 amplification in 20.6% of breast cancers.
17417639
2007
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
CausalMutation
CGI
×
Entrez Id:
2099
Gene Symbol:
ESR1
ESR1
Breast Carcinoma
0.700
GenomicAlterations
CGI