Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. 28825726

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Sox2-promoted Cre-expressing hemizygous males were mated with floxed brca1 females, and gestational day 8 +/- brca1 conditional knockout embryos with a 28% reduction in protein expression were exposed in culture to the reactive oxygen species (ROS)-initiating drug ethanol (EtOH). 26629949

2016

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human These results validate the concept of using pigs as a model to study BRCA1 defects in breast cancer and establish the first porcine breast tumor cell line. 26379698

2015

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Prevalence of BRCA mutations in an unselected population of triple-negative breast cancer. 22614657

2012

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human To investigate the predictive value of breast cancer susceptibility gene 1 (BRCA1) and class IIIβ-tubulin protein expression in tumor tissue for the efficacy of taxol and cisplatin combined chemotherapy (TP) in stage IIIB/IV non-small cell lung cancer (NSCLC) patients. 21781528

2011

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Immunophenotypic predictive profiling of BRCA1-associated breast cancer. 20941507

2011

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer. 20135344

2010

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. 18066063

2008

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. 15750629

2005

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Increased rates of chromosome breakage in BRCA1 carriers are normalized by oral selenium supplementation. 15894690

2005

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 10788334

2000

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. 7894491

1994

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GenomicAlterations CGI

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 CausalMutation CGI