Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Discovery at the interface: Toward novel anti-proliferative agents targeting human estrogen receptor/S100 interactions. 27580430

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Activating ESR1 mutations in hormone-resistant metastatic breast cancer. 24185510

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. 24185512

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. 23001124

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human The Possible Impact of Obesity on Androgen, Progesterone and Estrogen Receptors (ERα and ERβ) Gene Expression in Breast Cancer Patients. 22174584

2012

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions. 22038807

2012

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Significance of estrogen receptor 1 (ESR-1) gene imbalances in colon and hepatocellular carcinomas based on tissue microarrays analysis. 20458558

2012

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human ESR1 amplification is rare in breast cancer and is associated with high grade and high proliferation: a multiplex ligation-dependent probe amplification study. 20966540

2011

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. 21501481

2011

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human ESR1 amplification is rare in breast cancer and is associated with high grade and high proliferation: a multiplex ligation-dependent probe amplification study. 21541733

2011

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Quantitative profiles of the mRNAs of ER-alpha and its novel variant ER-alpha36 in breast cancers and matched normal tissues. 20104649

2010

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. 17417639

2008